Pathogen transmission from wildlife hosts to genetically distinct species is a major driver of
disease emergence. African swine fever virus (ASFV) persists in sub-Saharan Africa through …

The interferon pathway is the first line of defense in viral infection in all mammals, and its
induction stimulates broad expression of interferon-stimulated genes (ISGs). In mice and …

The use of vaccination against the influenza virus remains the most effective method of
mitigating the significant morbidity and mortality caused by this virus. Antibodies elicited by …

The acute antiviral response is mediated by a family of interferon-stimulated genes (ISGs),
providing cell-intrinsic immunity. Mutations in genes encoding these proteins are often …

Host interferon-induced transmembrane proteins (IFITMs) are broad-spectrum antiviral
restriction factors. Of these, IFITM3 potently inhibits viruses that enter cells through acidic …

The emergence of zoonotic strains of avian influenza (AI) that cause high rates of mortality in
people has caused significant global concern, with a looming threat that one of these strains …

The disease severity of influenza is highly variable in humans, and one genetic determinant
behind these differences is the IFITM3 gene. As an effector of the interferon response …

The threat of a new influenza pandemic is real. With past pandemics claiming millions of
lives, finding new ways to combat this virus is essential. Host cells have developed a multi …

BACKGROUND: Tetraspanin CD151 is highly expressed in endothelia and reinforces cell
adhesion, but its role in vascular inflammation remains largely unknown. METHODS: In vitro …

Species-specific interferon responses are shaped by the virus-host arms race. The human
interferon-induced transmembrane protein (IFITM) family consists of three antiviral IFITM …