The house dust mite (HDM) is a major perennial allergen source and a significant cause of
allergic rhinitis and allergic asthma. However, awareness of the condition remains generally …

Decades of research in animal models have provided abundant evidence to show that IL-13
is a key TH2 cytokine that directs many of the important features of airway inflammation and …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
dramatically changed our world, country, communities, and families. There is controversy …

Barrier tissue dysfunction is a fundamental feature of chronic human inflammatory diseases
1. Specialized subsets of epithelial cells—including secretory and ciliated cells …

Muco-obstructive lung diseases are typically associated with high risks of COVID-19
severity; however, allergic asthma showed reduced susceptibility. To investigate viral …

There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS …

Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug
research. A common approach is to infer signaling activity of pathways from gene …

Background Interleukin 13 is a central mediator of asthma. Tralokinumab is a human
interleukin-13 neutralising monoclonal antibody. We aimed to assess the efficacy and safety …

Background The Chr17q12-21.2 region is the strongest and most consistently associated
region with asthma susceptibility. The functional genes or single nucleotide polymorphisms …

The goal of cancer immunotherapy is to clear tumor cells by activating antitumor immunity,
especially by mobilizing tumor-reactive CD8+ T cells. Pyroptosis, programmed lytic cell …