Serine proteases and their natural protein inhibitors are among the most intensively studied
protein complexes. About 20 structurally diverse inhibitor families have been identified …

The pancreatic Kunitz inhibitor, also known as aprotinin, bovine basic pancreatic trypsin
inhibitor (BPTI), and trypsin-kallikrein inhibitor, is one of the most extensively studied …

To the Editor: Reliable and fast computation of protein free energy is crucial for protein-
structure analysis, structure-based protein design and protein docking. Rigorous treatments …

Kunitz type proteins are an important group of ubiquitous protease inhibitors found spanning
the evolutionary tree from microbes to mammals. These proteins can have single or multiple …

Atomic resolution structures of trypsin acyl-enzymes and a tetrahedral intermediate analog,
along with previously solved structures representing the Michaelis complex, are used to …

The inherent instability of peptides toward metabolic degradation is an obstacle on the way
toward bringing potential peptide drugs onto the market. Truncation can be one way to …

Inhibitors of coagulation factors from blood-feeding animals display a wide variety of
structural motifs and inhibition mechanisms. We have isolated a novel inhibitor from the …

New tick and tick-borne pathogen control approaches that are both environmentally
sustainable and which provide broad protection are urgently needed. Their development …

Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of
livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human …

Tissue factor pathway inhibitor-2 (TFPI-2) is a 32 kDa matrix-associated Kunitz-type serine
proteinase inhibitor consisting of a short amino-terminal region, three tandem Kunitz-type …