With aging, the kidney undergoes inexorable and progressive changes in structural and
functional performance. These aging‐related alterations are more obvious and serious in …

Background Diabetic nephropathy (DN) is a chronic microvascular complication caused by
long-term hyperglycemia in patients with diabetes and an important cause of end-stage …

Diabetic nephropathy (DN) is a common microvascular complication in the late stages of
diabetes. Currently, the etiology and pathogenesis of DN are not well understood. Even so …

Klotho, encoded by the klotho gene, is associated with phosphate homeostasis. Klotho acts
as a co-receptor for FGF23 for binding to its receptors. With FGF23, klotho regulates the …

Despite emerging evidence suggesting that autophagy occurs during renal interstitial
fibrosis, the role of autophagy activation in fibrosis and the mechanism by which autophagy …

Objectives To identify biomarkers of renal disease in adolescents with type 1 diabetes (T1D)
and to compare findings in adults with T1D. Methods Twenty‐five serum biomarkers were …

Fibroblast growth factors (FGFs) 21 and 23 are recently identified hormones regulating
metabolism of glucose, lipid, phosphate and vitamin D. Here we conducted a genome-wide …

Whether Klotho plays any role in hypothyroidism is unknown. This study aimed to determine
the relationship between serum Klotho levels and hypothyroidism in older adults. From the …

Introduction Fibroblast growth factor 23 (FGF23) gene variants could influence the
production of FGF23 in subjects at risk for chronic kidney disease (CKD). Our purpose was …

Purpose The aim of our study is to evaluate whether serum Klotho/FGF-23 and apelin-13
can be used as new biomarkers for detection of development of nephropathy. Methods In …