Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation

JAHR Claassen, DHJ Thijssen… - Physiological …, 2021 - journals.physiology.org
Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Cerebrovascular reactivity measurement using magnetic resonance imaging: a systematic review

E Sleight, MS Stringer, I Marshall, JM Wardlaw… - Frontiers in …, 2021 - frontiersin.org
Cerebrovascular reactivity (CVR) magnetic resonance imaging (MRI) probes cerebral
haemodynamic changes in response to a vasodilatory stimulus. CVR closely relates to the …

MRI of healthy brain aging: A review

ME MacDonald, GB Pike - NMR in Biomedicine, 2021 - Wiley Online Library
We present a review of the characterization of healthy brain aging using MRI with an
emphasis on morphology, lesions, and quantitative MR parameters. A scope review found …

Atrial Fibrillation and Cognitive Function: JACC Review Topic of the Week

HC Diener, RG Hart, PJ Koudstaal, DA Lane… - Journal of the American …, 2019 - jacc.org
Numerous vascular risk factors and vascular diseases contribute to cognitive impairment
and dementia. Many studies and registries show an association of atrial fibrillation (AF) with …

Genetic evidence for causal association between atrial fibrillation and dementia: a Mendelian randomization study

M Li, C Jiang, Y Lai, Y Wang, M Zhao, S Li… - Journal of the …, 2023 - Am Heart Assoc
Background The knowledge gap regarding whether the correlation between atrial fibrillation
(AF) and dementia in observational studies is causation or driven by other shared risk …

Atrial fibrillation, antithrombotic treatment, and cognitive aging: a population-based study

M Ding, L Fratiglioni, K Johnell, G Santoni, J Fastbom… - Neurology, 2018 - AAN Enterprises
Objective To examine the association of atrial fibrillation (AF) with cognitive decline and
dementia in old age, and to explore the cognitive benefit of antithrombotic treatment in …

Is it good to have a stiff aorta with aging? Causes and consequences

GL Pierce, TA Coutinho, LE DuBose… - Physiology, 2022 - journals.physiology.org
Aortic stiffness increases with advancing age, more than doubling during the human life
span, and is a robust predictor of cardiovascular disease (CVD) clinical events independent …

Cognitive dysfunction in atrial fibrillation

M Madhavan, J Graff-Radford, JP Piccini… - Nature Reviews …, 2018 - nature.com
Atrial fibrillation (AF) is the most common arrhythmia in adults, and its incidence and
prevalence increase with age. The risk of cognitive impairment and dementia also increases …

[HTML][HTML] Cerebral small vessel disease in sporadic and familial Alzheimer disease

RN Kalaria, D Sepulveda-Falla - The American journal of pathology, 2021 - Elsevier
Alzheimer disease (AD) is the most common cause of dementia. Biological definitions of AD
are limited to the cerebral burden of amyloid β plaques, neurofibrillary pathology, and …

Alzheimer's dementia: pathogenesis and impact of cardiovascular risk factors on cognitive decline

P Wanleenuwat, P Iwanowski… - Postgraduate …, 2019 - Taylor & Francis
Alzheimer's disease (AD) is the most common form of dementia manifesting as alterations in
cognitive abilities, behavior, and deterioration in memory which is progressive, leading to …