The integrated stress response (ISR) refers to signaling pathways initiated by stress-
activated eIF2α kinases. Distinct eIF2α kinases respond to different stress signals, including …

Methionine synthases (MetH) catalyse the methylation of homocysteine (Hcy) with 5-methyl-
tetrahydrofolate (5, methyl-THF) acting as methyl donor, to form methionine (Met) and …

Cells contain disparate amounts of distinct amino acids, each of which has different
metabolic and chemical origins, but the supply cost vs demand requirements of each is …

Komagataella phaffii yeast plays a prominent role in modern biotechnology as a
recombinant protein producer. For efficient use of this yeast, it is essential to study the effects …

Gcn4p belongs to conserved AP-1 transcription factors involved in many cellular processes,
including cell proliferation, stress response, and nutrient availability in yeast and mammals …

Nitrogen serves as a pivotal nutrient for the proliferation, maturation, and pathogenicity of
fungi. Despite its importance, nitrogen starvation is a common challenge encountered during …

Cells require disparate amounts of distinct amino acids, which themselves have discrete
biosynthetic costs. However, it remains unclear if and how cells respond differently to their …

Cells must constantly modulate their gene expression in response to ever-shifting
environmental conditions. In order to do so, cells require mechanisms to relay information …