The cytokine network in acute myeloid leukemia
M Luciano, PW Krenn, J Horejs-Hoeck - Frontiers in immunology, 2022 - frontiersin.org
Acute myeloid leukemia (AML) is a highly heterogeneous malignancy of the blood and bone
marrow, characterized by clonal expansion of myeloid stem and progenitor cells and rapid …
marrow, characterized by clonal expansion of myeloid stem and progenitor cells and rapid …
A role for the bone marrow microenvironment in drug resistance of acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis and
remarkable resistance to chemotherapeutic agents. Understanding resistance mechanisms …
remarkable resistance to chemotherapeutic agents. Understanding resistance mechanisms …
Combining empirical knowledge, in silico molecular docking and ADMET profiling to identify therapeutic phytochemicals from Brucea antidysentrica for acute myeloid …
Acute myeloid leukemia (AML) is one of the deadly cancers. Chemotherapy is the first-line
treatment and the only curative intervention is stem cell transplantation which are intolerable …
treatment and the only curative intervention is stem cell transplantation which are intolerable …
Cinobufagin inhibits proliferation of acute myeloid leukaemia cells by repressing c-Myc pathway-associated genes
Y Hirasaki, A Okabe, M Fukuyo, B Rahmutulla… - Chemico-Biological …, 2022 - Elsevier
Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad, Bufo
gargarizans. Bufanolides inhibit Na+/K+ ATPase and have similar effects as cardiac …
gargarizans. Bufanolides inhibit Na+/K+ ATPase and have similar effects as cardiac …
A phase 1B clinical study of combretastatin A1 diphosphate (OXi4503) and cytarabine (ARA-C) in combination (OXA) for patients with relapsed or refractory acute …
Combretastatin A1 (OXi4503) is a dual-function drug with vascular disrupting and cytotoxic
properties that has exhibited single-agent anti-leukemia activity in murine xenograft models …
properties that has exhibited single-agent anti-leukemia activity in murine xenograft models …
MicroRNAs: pivotal regulators in acute myeloid leukemia
M Li, X Cui, H Guan - Annals of Hematology, 2020 - Springer
MicroRNAs are a class of small non-coding RNAs that are 19–22 nucleotides in length and
regulate a variety of biological processes at the post-transcriptional level. MicroRNA …
regulate a variety of biological processes at the post-transcriptional level. MicroRNA …
Current and emerging molecular and epigenetic disease entities in acute myeloid leukemia and a critical assessment of their therapeutic modalities
X Zhao, H Liu, LN Wang, L Yang, X Liu - Seminars in Cancer Biology, 2022 - Elsevier
Acute myeloid leukemia (AML) is the most frequently diagnosed acute leukemia, and its
incidence increases with age. Although the etiology of AML remains unknown, exposure to …
incidence increases with age. Although the etiology of AML remains unknown, exposure to …
DOT1L inhibitors block abnormal self-renewal induced by cohesin loss
KE Heimbruch, JB Fisher, CT Stelloh, E Phillips… - Scientific Reports, 2021 - nature.com
Acute myeloid leukemia (AML) is a high-risk malignancy characterized by a diverse
spectrum of somatic genetic alterations. The mechanisms by which these mutations …
spectrum of somatic genetic alterations. The mechanisms by which these mutations …
Long non-coding RNA LINC01268 promotes cell growth and inhibits cell apoptosis by modulating miR-217/SOS1 axis in acute myeloid leukemia
B Chen, Y Li, Y Nie, A Tang, Q Zhou - Brazilian Journal of Medical and …, 2020 - SciELO Brasil
The aim of this study was to evaluate the pathogenic role of newly identified long non-coding
(lnc)-RNA LINCO1268 in acute myeloid leukemia (AML), and investigate its therapeutic …
(lnc)-RNA LINCO1268 in acute myeloid leukemia (AML), and investigate its therapeutic …
Comprehensive analysis the potential biomarkers for the high-risk of childhood acute myeloid leukemia based on a competing endogenous RNA network
N Zhang, Y Chen, Y Shen, S Lou, J Deng - Blood Cells, Molecules, and …, 2019 - Elsevier
Acute myeloid leukemia (AML) is a common form of hematological malignancies, the
discovery of non-coding RNA (ncRNA) plays an important role in diverse biological …
discovery of non-coding RNA (ncRNA) plays an important role in diverse biological …