Breakthroughs in materials engineering have accelerated the progress of immunotherapy in
preclinical studies. The interplay of chemistry and materials has resulted in improved …

The development of therapeutic cancer vaccines as a means to generate immune reactivity
against tumors has been explored since the early discovery of tumor-specific antigens by …

Nanoparticle-based delivery systems for cancer immunotherapies aim to improve the safety
and efficacy of these treatments through local delivery to specialized antigen-presenting …

Motivation Reverse vaccinology (RV) is a milestone in rational vaccine design, and machine
learning (ML) has been applied to enhance the accuracy of RV prediction. However, ML …

In recent years, personalized cancer vaccines have gained increasing attention as emerging
immunotherapies with the capability to overcome interindividual differences and show great …

Nowadays, immunotherapy is one of the most essential treatments for various diseases and
a broad spectrum of disorders are assumed to be treated by altering the function of the …

Currently approved replication-competent and inactivated vaccines are limited by excessive
reactogenicity and poor safety profiles, while subunit vaccines are often insufficiently …

Peptide-based subunit vaccines utilise minimal immunogenic components (ie peptides) to
generate highly specific immune responses, without triggering adverse reactions. However …

The utility of layer-by-layer (LbL) coated microneedle (MN) skin patches for transdermal drug
delivery has proven to be a promising approach, with advantages over hypodermal injection …

The in vivo implanted biomaterials are known to induce inflammatory response and recruit
immune cells, which could be used as robust adjuvants for immunotherapy. However, the …