NMDA-type glutamate receptors (NMDARs) mediate many forms of synaptic plasticity. These
tetrameric receptors consist of two obligatory NR1 subunits and two regulatory subunits …

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter that is required for
the control of synaptic excitation/inhibition and neural oscillation. GABA is synthesized by …

The operation of a glutamine–glutamate/GABA cycle in the brain consisting of the transfer of
glutamine from astrocytes to neurons and neurotransmitter glutamate or GABA from neurons …

Schizophrenia is a brain disorder associated with cognitive deficits that severely affect the
patients′ capacity for daily functioning. Whereas our understanding of its pathophysiology …

The 67 and 65 kDa isoforms of glutamic acid decarboxylase, the key enzymes for GABA
biosynthesis, are expressed at altered levels in postmortem brain of subjects diagnosed with …

We studied the role of sensory experience in the maturation of GABAergic circuits in the rat
visual cortex. Between the time at which the eyes first open and the end of the critical period …

Visual system circuitry, a canonical model system for the study of experience-dependent
development, matures before and following the onset of vision. Sensory experience or …

l-Glutamic acid decarboxylase (GAD) exists as both membrane-associated and soluble
forms in the mammalian brain. Here, we propose that there is a functional and structural …

What causes critical periods (CPs) to open? For the best-studied case, ocular dominance
plasticity in primary visual cortex in response to monocular deprivation (MD), the maturation …

Monocular deprivation in mice between postnatal days 19 and 32 has been reported to
significantly shift ocular dominance within the binocular region of primary visual cortex; …