Discovery and design of radiopharmaceuticals by in silico methods

M Salahinejad, DA Winkler… - Current …, 2022 - ingentaconnect.com
There has been impressive growth in the use of radiopharmaceuticals for therapy, selective
toxic payload delivery, and noninvasive diagnostic imaging of disease. The increasing …

Preparation and preliminary evaluation study of [131I]iodocolchicine-gallic-AuNPs: a potential scintigraphic agent for inflammation detection

BM Essa, AA Selim, OA El-Kawy… - International journal of …, 2022 - Taylor & Francis
Background Nanomedicine offers great potential for scintigraphic diagnostic imaging with
lower risk and higher quality compared to other traditional techniques. Objectives This work …

Radiolabeling, characterization, and preclinical evaluation of plazomicin: A potential tracer for bacterial infection

OA El‐kawy, G Abdelaziz… - Chemical Biology & …, 2022 - Wiley Online Library
In this study, 99mTc–plazomicin, a new radio‐antibiotic complex, was prepared specifically
for bacterial infection localization and monitoring. Factors affecting the labeling reaction …

Preparation and evaluation of 99mTc-anidulafungin: a potential radiotracer for fungal infection

OA El-Kawy, MS Sayed, AS Abdel-Razek - Journal of Radioanalytical and …, 2020 - Springer
Aiming to develop specific diagnostic tool for invasive fungal infection, a
radiopharmaceutical based on anidulafungin was investigated. A two-step approach was …

Preparation and evaluation of radioiodinated avanafil: A novel potential radiopharmaceutical for the diagnostic evaluation of erectile dysfunction

OA El-Kawy, IT Ibrahim, HA Shewatah… - Applied Radiation and …, 2022 - Elsevier
Avanafil, a selective second-generation phosphodiesterase-5 inhibitor, was successfully
labeled with iodine-125 via electrophilic and different factors affecting the labeling efficiency …

Quantifying AMPARs with 99mTc-omberacetam: a novel diagnostic radiotracer for ischemic stroke

HF Azhari, AM Hashem - Journal of Umm Al-Qura University for Applied …, 2024 - Springer
Synaptic trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
(AMPARs) is thought to cause excitotoxicity brain ischemia. However, given the current …

Radiolabeling and evaluation of fonturacetam hydrazide as a radiotracer for visualization of brain function

OA El-Kawy, HA Shweeta, KM Sallam - Journal of Radioanalytical and …, 2023 - Springer
Abstract [99mTc] fonturacetam hydrazide was radiosynthesized to assess neuropsychiatric
disorders by targeting the brain. The nootropic drug was labeled with technetium-99m, and …

99mTc-Avanafil as a Potential Tracer for Erectile Dysfunction: Synthesis, Characterization, and Evaluation

OA El-Kawy, IT Ibrahim, SM Abd-Elhaliem, KM Attallah - Radiochemistry, 2023 - Springer
Avanafil was labeled with technetium-99m for diagnostic evaluation of erectile dysfunction.
The labeling conditions were optimized to reach a high radiolabeling yield (98.6%). The …

Preparation and Evaluation of 177Lu-TDTMP: A Potential Theranostic Agent for Bone Metastases

H Talaat - Arab Journal of Nuclear Sciences and Applications, 2019 - ajnsa.journals.ekb.eg
177Lu was produced in high-specific activity and excellent radionuclidic purity by thermal
neutron bombardment of 176Yb target. Tetramethylene diamine tetramethylenephosphonic …