All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …

An incomplete view of the mechanisms that drive metastasis, the primary cause of cancer-
related death, has been a major barrier to development of effective therapeutics and …

To increase understanding of the genomic landscape of acral melanoma, a rare form of
melanoma occurring on palms, soles or nail beds, whole genome sequencing of 87 tumors …

In recent years, our vision of lysosomes has drastically changed. Formerly considered to be
mere degradative compartments, they are now recognized as key players in many cellular …

Certain transcription factors have vital roles in lineage development, including specification
of cell types and control of differentiation. Microphthalmia-associated transcription factor …

Aberrant expression of embryonic epithelial-mesenchymal transition-inducing transcription
factors (EMT-TFs) in epithelial cells triggers EMT, neoplastic transformation, stemness, and …

In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular
signals are transduced via dedicated signalling pathways and mostly converge to MITF, a …

Melanocyte development provides an excellent model for studying more complex
developmental processes. Melanocytes have an apparently simple aetiology, differentiating …

Fish coloration, evolved from selection and adaptation, is a prominent feature of remarkable
aquaculture merits. Fish possess more pigment cell types than any other vertebrates and are …

The neural crest (NC) is a transient, multipotent and migratory cell population that generates
an astonishingly diverse array of cell types during vertebrate development. These cells …