Molecular frustration: a hypothesis for regulation of viral infections

R Twarock, GJ Towers, PG Stockley - Trends in Microbiology, 2024 - cell.com
The recent revolution in imaging techniques and results from RNA footprinting in situ reveal
how the bacteriophage MS2 genome regulates both particle assembly and genome release …

3D Puzzle at the Nanoscale–how do RNA Viruses Self‐Assemble their Capsids into Perfectly Ordered Structures

M Kordys, A Urbanowicz - Macromolecular Bioscience, 2024 - Wiley Online Library
The phenomenon of RNA virus self‐organization, first observed in the mid‐20th century in
tobacco mosaic virus, is the subject of extensive research. Efforts to comprehend this …

[HTML][HTML] Visualizing Viral RNA Packaging Signals in Action

E Wroblewski, N Patel, A Javed, CP Mata… - Journal of Molecular …, 2024 - Elsevier
Here we confirm, using genome-scale RNA fragments in assembly competition assays, that
multiple sub-sites (Packaging Signals, PSs) across the 5′ two-thirds of the gRNA of …

The Multiple Regulatory Roles of Single-Stranded RNA Viral Genomes in Virion Formation and Infection

PG Stockley, R Twarock - Physical Virology: From the State-of-the-Art …, 2023 - Springer
We describe our discovery, recent findings, and potential implications, of previously
unsuspected roles of viral genomes in assembly regulation and infection. For a range of viral …