As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

Hundreds of nucleus‐encoded mitochondrial precursor proteins are synthesized in the
cytosol and imported into mitochondria in a post‐translational manner. However, the early …

Mitochondria perform crucial functions in cellular metabolism, protein and lipid biogenesis,
quality control, and signaling. The systematic analysis of protein complexes and interaction …

Mitochondria require the constant import of nuclear-encoded proteins for proper functioning.
Impaired protein import not only depletes mitochondria of essential factors but also leads to …

Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into
mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the …

Protein homeostasis (proteostasis) is a dynamic balance of protein synthesis and
degradation. Because of the endosymbiotic origin of chloroplasts and the massive transfer of …

Mitochondrial biogenesis requires the import of> 1,000 mitochondrial preproteins from the
cytosol. Most studies on mitochondrial protein import are focused on the core import …

Mitochondria import 1000–1300 different precursor proteins from the cytosol. The main
mitochondrial entry gate is formed by the translocase of the outer membrane (TOM …

The abundance of each cellular protein is dynamically adjusted to the prevailing metabolic
and stress conditions by modulation of their synthesis and degradation rates. The …