Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms
D Ezhilarasan - Toxicology, 2021 - Elsevier
Methotrexate (MTX) is one of the most effective and widely used drugs in the management of
autoimmune and dermatological diseases. Rheumatoid arthritis and psoriasis patients who …
autoimmune and dermatological diseases. Rheumatoid arthritis and psoriasis patients who …
Insights gained into the injury mechanism of drug and herb induced liver injury in the hepatic microenvironment
X Zhang, Q Geng, L Lin, L Zhang, C Shi, B Liu, L Yan… - Toxicology, 2024 - Elsevier
Abstract Drug-Induced Liver Injury (DILI) and herb Induced Liver Injury (HILI) continues to
pose a substantial challenge in both clinical practice and drug development, representing a …
pose a substantial challenge in both clinical practice and drug development, representing a …
Ethanolic leaf extract of Datura stramonium attenuates methotrexate-induced biochemical alterations in Wistar Albino rats
Objectives Methotrexate (MTX) is a commonly used anti-cancer drug. However, its usage
could lead to various biochemical dysregulations culminating in organ toxicity. Globally …
could lead to various biochemical dysregulations culminating in organ toxicity. Globally …
[HTML][HTML] Nephroprotective effects of Datura stramonium leaves against methotrexate nephrotoxicity via attenuation of oxidative stress-mediated inflammation and …
Objective: Methotrexate (MTX) is a frontline antimetabolite anticancer drug which is used in
different cancer treatments but its nephrotoxicity is a notable drawback that limits its clinical …
different cancer treatments but its nephrotoxicity is a notable drawback that limits its clinical …
Antioxidant and anti-inflammatory effects of virgin coconut oil supplementation abrogate acute chemotherapy oxidative nephrotoxicity induced by anticancer drug …
AC Famurewa, PM Aja, EK Maduagwuna… - Biomedicine & …, 2017 - Elsevier
Background Methotrexate (MTX) is an efficacious anticancer agent constrained in clinical
use due to its toxicity on non-targeted tissue, a considerable source of worry to clinicians …
use due to its toxicity on non-targeted tissue, a considerable source of worry to clinicians …
[HTML][HTML] Captopril downregulates expression of Bax/cytochrome C/caspase-3 apoptotic pathway, reduces inflammation, and oxidative stress in cisplatin-induced acute …
BG Eid, NA El-Shitany - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Cisplatin (Cis) is an effective cancer therapy commonly employed in many therapeutic
regimens. However, treatment regimens that contain either a high dose or cumulative doses …
regimens. However, treatment regimens that contain either a high dose or cumulative doses …
Protective effects of magnesium glycyrrhizinate on methotrexate-induced hepatotoxicity and intestinal toxicity may be by reducing COX-2
Y Cao, H Shi, Z Sun, J Wu, Y Xia, Y Wang… - Frontiers in …, 2019 - frontiersin.org
Magnesium isoglycyrrhizinate (MgIG), which has been widely employed to treat chronic
hepatitis, is synthesized from 18-β glycyrrhizic acid, a main component of traditional Chinese …
hepatitis, is synthesized from 18-β glycyrrhizic acid, a main component of traditional Chinese …
[HTML][HTML] Ameliorating effects of tempol on methotrexate-induced liver injury in rats
Methotrexate (MTX) is used in the treatment of certain types of cancers and chronic
inflammatory illnesses, although the clinical use of MTX is limited due to its adverse effects …
inflammatory illnesses, although the clinical use of MTX is limited due to its adverse effects …
Telmisartan alleviates alcohol-induced liver injury by activation of PPAR-γ/Nrf-2 crosstalk in mice
Excessive consumption of alcohol may induce severe liver damage, in part via oxidative
stress and inflammatory responses, which implicates these processes as potential …
stress and inflammatory responses, which implicates these processes as potential …
Hepatoprotective effect of Ginkgo biloba extract against methotrexate-induced hepatotoxicity via targeting STAT3/miRNA-21 axis
IO Sherif, NH Al-Shaalan - Drug and chemical toxicology, 2022 - Taylor & Francis
The usage of the chemotherapeutic agent methotrexate (MTX) was associated with
hepatotoxicity that minimized its clinical use. The Ginkgo biloba extract (GBE) was used …
hepatotoxicity that minimized its clinical use. The Ginkgo biloba extract (GBE) was used …