Novel therapeutic combinations with PARP inhibitors for small cell lung cancer: A bench-to-bedside review

J Xiong, R Barayan, AV Louie, BH Lok - Seminars in cancer biology, 2022 - Elsevier
Small cell lung cancer (SCLC) is treated as a monolithic disease despite the evident intra-
and intertumoral heterogeneity. Non-specific DNA-damaging agents have remained the first …

Integrative experimental and computational analysis of the impact of KGM's polymerization degree on wheat starch's pasting and retrogradation characteristics

Y Zhao, J Wang, R He, Y Ren, J Fu, Y Zeng… - Carbohydrate …, 2024 - Elsevier
This study investigated the influence of Konjac Glucomannan (KGM) with varying degrees of
polymerization (DKGMx) on the gelatinization and retrogradation characteristics of wheat …

A Tandem-Affinity Purification Method for Identification of Primary Intracellular Drug-Binding Proteins

S Islam, J Gour, T Beer, HY Tang, J Cassel… - ACS Chemical …, 2024 - ACS Publications
In the field of drug discovery, understanding how small molecule drugs interact with cellular
components is crucial. Our study introduces a novel methodology to uncover primary drug …

Impact of a Cancer-Associated Mutation on Poly (ADP-ribose) Polymerase1 Inhibition

N Shanmugam, S Chatterjee, GA Cisneros - bioRxiv, 2024 - biorxiv.org
Poly (ADP-ribose) polymerase1 (PARP1) plays a vital role in DNA repair and its inhibition in
cancer cells may cause cell apoptosis. In this study, we investigated the effects of a PARP1 …