BACKGROUND One hundred years ago, experiments on beating frog hearts identified
acetylcholine (ACh) as the seminal neurotransmitter. Sixty years later, fractionation of the eel …

The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and
in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a …

Cholinergic receptors represent a promising class of diagnostic and therapeutic targets due
to their significant involvement in cognitive decline associated with neurological disorders …

Microglia as an important type of innate immune cell in the brain have been considered as
an effective therapeutic target for the treatment of central nervous degenerative diseases …

The main objective of this study was to determine the pharmacological activity and
molecular mechanism of action of DM506 (3-methyl-1, 2, 3, 4, 5, 6-hexahydroazepino [4, 5 …

The extracellular matrix has emerged as an active component of chemical synapses
regulating synaptic formation, maintenance, and homeostasis. The heparan sulfate …

Garcinol, a nicotinic acetylcholine receptor (nAChR) antagonist, has recently been
established as an anti-inflammation agent. However, the molecular mechanism by which …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of pentameric, ligand-
gated ion channels that are located on the surface of neurons and non-neuronal cells and …

A deficiency of the functional α7 nicotinic acetylcholine receptor (α7nAChR) impairs
neuronal and immune systems. The SARS-CoV-2 spike protein (S12) facilitates virus cell …

There is no definitive cure for cancer, and most of the current chemotherapy drugs have
limited effects due to the development of drug resistance and toxicity at high doses …