Obesity is a worldwide epidemic that predisposes individuals to cardiometabolic
complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease …

Type-2 diabetes (T2D) is a disease of two etiologies: metabolic and inflammatory. At the
cross-section of these etiologies lays the phenomenon of metabolic inflammation. Whilst …

Loss of LKB1 is associated with increased metastasis and poor prognosis in lung cancer,
but the development of targeted agents is in its infancy. Here we report that a glutaminolytic …

Background: Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient
procedures for treating morbid obesity and results in weight-loss and improvements in …

Anoikis is a type of programmed cell death induced by loss of anchorage to the extracellular
matrix (ECM). Anoikis resistance (AR) is crucial for the survival of metastatic cancer cells in …

TWIST1 is a basic helix-loop-helix (bHLH) transcription factor which plays essential and
pivotal roles in multiple stages of embryonic development, and significantly contributes to …

Proinflammatory cytokines are critically involved in the alteration of adipose tissue biology
leading to deterioration of glucose homeostasis in obesity. Here we show a pronounced …

Agonists of glucocorticoid receptor (GR) are frequently given to cancer patients with
platinum-containing chemotherapy to reduce inflammation, but how GR influences tumor …

Accumulation of visceral adipose tissue correlates with elevated inflammation and increased
risk of metabolic diseases. However, little is known about the molecular mechanisms that …

As most of the mitochondrial proteome is encoded in the nucleus, mitochondrial functions
critically depend on nuclear gene expression and bidirectional mito-nuclear communication …