Complex synthetic lethality in cancer
The concept of synthetic lethality has been widely applied to identify therapeutic targets in
cancer, with varying degrees of success. The standard approach normally involves …
cancer, with varying degrees of success. The standard approach normally involves …
[HTML][HTML] From Crypts to Cancer: A Holistic Perspective on Colorectal Carcinogenesis and Therapeutic Strategies
E Gharib, GA Robichaud - International journal of molecular sciences, 2024 - mdpi.com
Colorectal cancer (CRC) represents a significant global health burden, with high incidence
and mortality rates worldwide. Recent progress in research highlights the distinct clinical …
and mortality rates worldwide. Recent progress in research highlights the distinct clinical …
APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells
M Chen, T Mashima, T Oishi, Y Muramatsu… - British Journal of …, 2024 - nature.com
Background Aberrant WNT/β-catenin signaling drives carcinogenesis. Tankyrases poly
(ADP-ribosyl) ate and destabilize AXINs, β-catenin repressors. Tankyrase inhibitors block …
(ADP-ribosyl) ate and destabilize AXINs, β-catenin repressors. Tankyrase inhibitors block …
BET protein–dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer
S Morino, T Mashima, F Shirai, S Nagayama… - Cancer Letters, 2024 - Elsevier
WNT/β-catenin signaling is aberrantly activated in colorectal cancer (CRC) mainly by loss-of-
function mutations in adenomatous polyposis coli (APC) and is involved in tumor …
function mutations in adenomatous polyposis coli (APC) and is involved in tumor …
A Mouse Model for the Rapid and Binomial Assessment of Putative WNT/β-Catenin Signalling Inhibitors
Specific signalling thresholds of the WNT/β-catenin pathway affect embryogenesis and
tissue homeostasis in the adult, with mutations in this pathway frequently occurring in …
tissue homeostasis in the adult, with mutations in this pathway frequently occurring in …
An evolutionary perspective on the origin, conservation and binding partner acquisition of tankyrases
ST Sowa, C Bosetti, A Galera-Prat, MS Johnson… - Biomolecules, 2022 - mdpi.com
Tankyrases are poly-ADP-ribosyltransferases that regulate many crucial and diverse cellular
processes in humans such as Wnt signaling, telomere homeostasis, mitotic spindle …
processes in humans such as Wnt signaling, telomere homeostasis, mitotic spindle …
Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors
C Bosetti, D Kampasis, A Galera-Prat, SA Brinch… - bioRxiv, 2024 - biorxiv.org
Human diphtheria toxin-like ADP-ribosyltransferases, PARPs and tankyrases, transfer ADP-
ribosyl groups to other macromolecules, thereby controlling various signaling events in cells …
ribosyl groups to other macromolecules, thereby controlling various signaling events in cells …
[PDF][PDF] An Evolutionary Perspective on the Origin, Conservation and Binding Partner Acquisition of Tankyrases. Biomolecules 2022, 12, 1688
ST Sowa, C Bosetti, A Galera-Prat, MS Johnson… - 2022 - research.abo.fi
Tankyrases are poly-ADP-ribosyltransferases that regulate many crucial and diverse cellular
processes in humans such as Wnt signaling, telomere homeostasis, mitotic spindle …
processes in humans such as Wnt signaling, telomere homeostasis, mitotic spindle …
[PDF][PDF] Regulation of PARP1/2 and the tankyrases: emerging parallels
M Jessop, BJ Broadway, K Miller… - Biochemical …, 2024 - portlandpress.com
ADP-ribosylation is a prominent and versatile post-translational modification, which
regulates a diverse set of cellular processes. Poly-ADP-ribose (PAR) is synthesised by the …
regulates a diverse set of cellular processes. Poly-ADP-ribose (PAR) is synthesised by the …