Recent advances in the formulation of PLGA microparticles for controlled drug delivery

E Lagreca, V Onesto, C Di Natale, S La Manna… - Progress in …, 2020 - Springer
Polymeric microparticles (MPs) are recognized as very popular carriers to increase the
bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different …

HER3 in cancer: from the bench to the bedside

L Gandullo-Sánchez, A Ocaña, A Pandiella - Journal of Experimental & …, 2022 - Springer
The HER3 protein, that belongs to the ErbB/HER receptor tyrosine kinase (RTK) family, is
expressed in several types of tumors. That fact, together with the role of HER3 in promoting …

Enhanced efficacy and drug delivery with lipid coated mesoporous silica nanoparticles in cancer therapy

MU Amin, S Ali, MY Ali, I Tariq, U Nasrullah… - European Journal of …, 2021 - Elsevier
The exposure of cancer cells to subtherapeutic drug concentrations results in multidrug
resistance (MDR). The uniqueness of mesoporous silica nanoparticles (MSNPs) with larger …

Thermosensitive liposomes encapsulating hypericin: Characterization and photodynamic efficiency

AA Dayyih, M Alawak, AM Ayoub, MU Amin… - International journal of …, 2021 - Elsevier
The potent photodynamic properties of Hypericin (Hyp) elicit a range of light-dose-
dependent anti-tumor activities. However, its low water solubility hampers its broad …

Lipoparticles for synergistic chemo-photodynamic therapy to ovarian carcinoma cells: in vitro and in vivo assessments

S Ali, MU Amin, I Tariq, MF Sohail, MY Ali… - International journal …, 2021 - Taylor & Francis
Purpose Lipoparticles are the core-shell type lipid-polymer hybrid systems comprising
polymeric nanoparticle core enveloped by single or multiple pegylated lipid layers (shell) …

Engineered aptamers for molecular imaging

B Lin, F Xiao, J Jiang, Z Zhao, X Zhou - Chemical Science, 2023 - pubs.rsc.org
Molecular imaging, including quantification and molecular interaction studies, plays a crucial
role in visualizing and analysing molecular events occurring within cells or organisms, thus …

Brain targeting and Aβ binding bifunctional nanoparticles inhibit amyloid protein aggregation in APP/PS1 transgenic mice

X Zhang, X Zhang, Y Li, M Zhong, P Zhao… - ACS Chemical …, 2021 - ACS Publications
Alzheimer's disease (AD) is an insidious and progressive neurodegenerative disease with
few disease-modifying treatments. A variety of peptide/protein drugs have neuroprotective …

Recent Innovations of Mesoporous Silica Nanoparticles Combined with Photodynamic Therapy for Improving Cancer Treatment

DS Nady, A Hassan, MU Amin, U Bakowsky, SA Fahmy - Pharmaceutics, 2023 - mdpi.com
Cancer is a global health burden and is one of the leading causes of death. Photodynamic
therapy (PDT) is considered an alternative approach to conventional cancer treatment. PDT …

Emerging tendencies for the nano-delivery of gambogic acid: a promising approach in oncotherapy

SA Fahmy, R Elghanam, G Rashid, RA Youness… - RSC …, 2024 - pubs.rsc.org
Despite the advancements in cancer therapies during the past few years, chemo/photo
resistance, severe toxic effects, recurrence of metastatic tumors, and non-selective targeting …

Design of an electrochemical aptasensor in the presence of an array of gold nanostructure and a GO-MWCNTs nanocomposite: application in diagnosis of Alzheimer's …

M Negahdary, RM Buoro, RP Bacil, BG Santos… - Microchimica Acta, 2023 - Springer
Alzheimer's disease (AD) is considered one of the main progressive chronic diseases in
elderly individuals. Early diagnosis using related biomarkers, specifically beta-amyloid …