RNA helicases constitute a large family of proteins that play critical roles in mediating RNA
function. They have been implicated in all facets of gene expression pathways involving …

RNA helicases are ubiquitous, highly conserved RNA-binding enzymes that use the energy
derived from the hydrolysis of nucleoside triphosphate to modify the structure of RNA …

The PI3K/Akt/mTOR kinase pathway is extensively deregulated in human cancers. One
critical node under regulation of this signaling axis is eukaryotic initiation factor (eIF) 4F, a …

Drug repurposing is a promising approach towards the discovery of novel treatments against
Neglected Tropical Diseases, such as Leishmaniases, presenting the advantage of reducing …

Leishmaniases are neglected diseases, caused by intracellular protozoan parasites of the
Leishmania (L.) genus. Although the principal host cells of the parasites are macrophages …

The protozoan parasite Leishmania donovani (L. donovani) causes visceral leishmaniasis, a
chronic infection which is fatal when untreated. Herein, we investigated whether in addition …

The shikimate pathway consists of seven enzymatic steps involved in the conversion of
erythrose-4-phosphate and phosphoenolpyruvate to chorismate and also responsible to the …

During three decades, only about 20 new drugs have been developed for malaria,
tuberculosis and all neglected tropical diseases (NTDs). This critical situation was reached …

The antifungal agent 6-aminocholestanol targets the production of ergosterol, which is the
principle sterol in many fungi and protozoans; ergosterol serves many of the same roles as …

The global prevalence of leishmaniasis has increased with skyrocketed mortality in the past
decade. The causative agent of leishmaniasis is Leishmania species, which infects …