The transcriptional co-regulators YAP and TAZ pair primarily with the TEAD family of
transcription factors to elicit a gene expression signature that plays a prominent role in …

The tumour microenvironment plays a critical role in determining tumour fate. Within that
environment, and indeed throughout epithelial tissues, cells experience competition with …

Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
are the downstream effectors of the Hippo signaling pathway that play a crucial role in …

Background The mechanism of metabolism reprogramming is an unsolved problem in clear
cell renal cell carcinoma (ccRCC). Recently, it was discovered that the Hippo pathway …

TEADs are transcription factors and core downstream components of the Hippo pathway.
Mutations of the Hippo pathway and/or dysregulation of YAP/TAZ culminate in aberrant …

Our understanding of cancer and the key pathways that drive cancer survival has expanded
rapidly over the past several decades. However, there are still important challenges that …

Simple Summary The low survival rate of osteosarcoma (OS) patients underlines the
urgency of developing new therapeutic strategies for this disease. In recent years, the …

Recent studies have suggested that Hippo signaling is not only involved in controlling organ
size in Drosophila but can also regulate cell proliferation, tissue homeostasis, differentiation …

As a highly conserved signaling network across different species, the Hippo pathway is
involved in various biological processes. Dysregulation of the Hippo pathway could lead to a …

A key hallmark of many diseases, especially those in the central nervous system (CNS), is
the change in tissue stiffness due to inflammation and scarring. However, how such changes …