Oral anticoagulants are a mainstay of cardiovascular therapy, and for over 60 years vitamin
K antagonists (VKAs) were the only available agents for long-term use. VKAs interfere with …

Many genetic variants in drug metabolizing enzymes and transporters have been shown to
be relevant for treating psychiatric disorders. Associations are strong enough to feature on …

Advances in understanding the molecular basis of rare and common disorders, as well as in
the technology of DNA analysis, are rapidly changing the landscape of molecular genetic …

Coumarins are a large group of substances, primarily of plant origin. Like their more
intensively examined congeners flavonoids, many of them are antioxidants. Although such …

Abacavir is a nucleoside analogue reverse transcriptase inhibitor indicated for the treatment
of human immunodeficiency virus infection as part of a multidrug, highly active antiretroviral …

There has been a 3-fold increase in hospital discharges for heart failure (HF) and also
significantly increased mortality rate in HF patients in recent years. A major focus of HF …

The genes encoding the cytochrome P450 2C9 enzyme (CYP2C9) and vitamin K-epoxide
reductase complex unit 1 (VKORC1) are major determinants of anticoagulant response to …

Warfarin is an oral anticoagulant frequently used in the treatment of different cardiovascular
diseases. Genetic polymorphisms in the CYP2C9 and VKORC1 genes have produced …

Background Single nucleotide polymorphisms in the vitamin K epoxide reductase (VKOR)
gene have been successfully used for warfarin dosage prediction. However, warfarin …

Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction,
Second Edition, provides a comprehensive review of the factors leading to errors in all areas …