Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and
luminal exposures but converge on a shared transcriptional program, including expression …

Triple-negative breast cancer (TNBC) is one of the most fatal and aggressive type of cancer
in younger population. TNBC is poorly diagnosed, detected only at later stages with low …

The cancer stem cell (CSC) hypothesis is an evolving oncogenesis concept. CSCs have a
distinct ability to self-renew themselves and also give rise to a phenotypically diverse …

Background: A critical unmet medical need in clinical management of colorectal cancer
(CRC) pivots around lack of noninvasive and or minimally invasive techniques for early …

While significant strides have been made in understanding cancer biology, the
enhancement in patient survival is limited, underscoring the urgency for innovative …

Diabetic cardiomyopathy (DCM) is a pathophysiological condition triggered by diabetes
mellitus and can lead to heart failure. Doublecortin-like kinase protein 1 (DCLK1) is a …

Tuft cells are more than guardian chemosensory elements of the digestive tract. They
produce a variety of immunological effector molecules in response to stimulation; moreover …

Germline variants in the NSD1 gene are responsible for Sotos syndrome, while somatic
variants promote neoplastic cell transformation. Our previous studies revealed three …

Background Oral squamous cell carcinoma (OSCC) is a frequently-diagnosed malignancy
with high potential for proliferation and invasion. Histone methylation is known as a crucial …

Recent research has shown that Doublecortin-like kinase 1 (DCLK1) is overexpressed in
different types of cancer. It has recently been described as a cancer stem cells (CSCs) …