Dual role of transient receptor potential ankyrin 1 in respiratory and gastrointestinal physiology: From molecular mechanisms to therapeutic targets
KR Tekulapally, JY Lee, DS Kim, MM Rahman… - Frontiers in …, 2024 - frontiersin.org
The transient receptor potential ankyrin 1 (TRPA1) channel plays a pivotal role in the
respiratory and gastrointestinal tracts. Within the respiratory system, TRPA1 exhibits diverse …
respiratory and gastrointestinal tracts. Within the respiratory system, TRPA1 exhibits diverse …
Neuronal and non-neuronal TRPA1 as therapeutic targets for pain and headache relief
LF Iannone, R Nassini, R Patacchini, P Geppetti… - Temperature, 2023 - Taylor & Francis
The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of
channels, has a major role in different types of pain. TRPA1 is primarily localized to a …
channels, has a major role in different types of pain. TRPA1 is primarily localized to a …
Complex regulatory role of the TRPA1 receptor in acute and chronic airway inflammation mouse models
The Transient Receptor Potential Ankyrin 1 (TRPA1) cation channel expressed on capsaicin-
sensitive afferents, immune and endothelial cells is activated by inflammatory mediators and …
sensitive afferents, immune and endothelial cells is activated by inflammatory mediators and …
Mini review: neural mechanisms underlying airway hyperresponsiveness
Neural changes underly hyperresponsiveness in asthma and other airway diseases.
Afferent sensory nerves, nerves within the brainstem, and efferent parasympathetic nerves …
Afferent sensory nerves, nerves within the brainstem, and efferent parasympathetic nerves …
High concentrations of ammonia induced cytotoxicity and bronchoconstriction in a precision-cut lung slices rat model
L Ågren, L Elfsmark, C Akfur, S Jonasson - Toxicology Letters, 2021 - Elsevier
Exposure to high concentrations of ammonia (NH 3) can cause life-threatening lung
damages. The objective of this study was to establish a translational in vitro model for NH 3 …
damages. The objective of this study was to establish a translational in vitro model for NH 3 …
[PDF][PDF] 瞬时受体电位通道在呼吸系统疾病中的作用研究进展
杨维杰， 骆媛， 王永安 - 中国药理学与毒理学杂志, 2021 - cjpt.magtechjournal.com
瞬时受体电位(TRP) 离子通道是一类非特异性的阳离子通道蛋白家族, 在呼吸道感觉神经纤维和
非神经细胞中广泛表达, 能响应多种刺激, 从而参与呼吸系统疾病的发生发展过程. 其中TRPA1 …
非神经细胞中广泛表达, 能响应多种刺激, 从而参与呼吸系统疾病的发生发展过程. 其中TRPA1 …
[HTML][HTML] Modulation of carbachol-induced Ca2+ oscillations in airway smooth muscle cells by PGE2
LM Morgan, SL Martin, ND Mullins, MA Hollywood… - Cell Calcium, 2022 - Elsevier
PGE 2 is a potent bronchodilator, but the mechanisms underlying this effect have not been
fully elucidated. Acetylcholine-induced contractions of airway smooth muscle (ASM) are …
fully elucidated. Acetylcholine-induced contractions of airway smooth muscle (ASM) are …
[HTML][HTML] Allyl isothiocyanate, an activator of TRPA1, increases gastric mucosal blood flow through calcitonin gene-related peptide and adrenomedullin in anesthetized …
N Ohashi, K Tashima, T Namiki, S Horie - Journal of Pharmacological …, 2023 - Elsevier
Allyl isothiocyanate (AITC) activates transient receptor potential ankyrin 1 (TRPA1) channel,
which is involved in the control of intestinal mucosal blood flow. However, the mechanism …
which is involved in the control of intestinal mucosal blood flow. However, the mechanism …
Extracellular acidification attenuates bronchial contraction via an autocrine activation of EP2 receptor: Its diminishment in murine experimental asthma
Y Chiba, Y Yamane, T Sato, W Suto, M Hanazaki… - Respiratory Physiology …, 2024 - Elsevier
Purpose Extracellular acidification is a major component of tissue inflammation, including
airway inflammation in asthmatics. However, its physiological/pathophysiological …
airway inflammation in asthmatics. However, its physiological/pathophysiological …
[HTML][HTML] 以胸闷为特点的胸闷变异性哮喘发病机制研究进展
车鸾卿， 赖建幸， 黄华琼， 李雯… - Journal of Zhejiang …, 2024 - ncbi.nlm.nih.gov
胸闷变异性哮喘（ CTVA） 是以胸闷为唯一或主要表现的不典型哮喘。 胸闷的潜在感受器是
支气管C 纤维或快适应受体， 神经冲动通过迷走神经上传， 神经中枢可能在大脑皮质中的几个 …
支气管C 纤维或快适应受体， 神经冲动通过迷走神经上传， 神经中枢可能在大脑皮质中的几个 …