GABA A receptors are ligand-gated ion channels composed of five subunits that can be
opened by GABA and be modulated by multiple pharmacologically and clinically important …

Gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter in the mammalian
central nervous system, plays a key role in the regulation of neuronal transmission …

Propofol is the most important intravenous general anesthetic in current clinical use. It acts
by potentiating GABAA (γ-aminobutyric acid type A) receptors, but where it binds to this …

Propofol acts as a positive allosteric modulator of γ-aminobutyric acid type A receptors
(GABA A Rs), an interaction necessary for its anesthetic potency in vivo as a general …

Glycinergic neurotransmission has long been known for its role in spinal motor control.
During the last two decades, additional functions have become increasingly recognized …

Atomic resolution structures of cys-loop receptors, including one of a γ-aminobutyric acid
type A receptor (GABAA receptor) subtype, allow amazing insights into the structural …

Diminished inhibitory control of spinal nociception is one of the major culprits of chronic pain
states. Restoring proper synaptic inhibition is a well-established rational therapeutic …

General anesthetics are a class of drugs that target the central nervous system and are
widely used for various medical procedures. General anesthetics produce many behavioral …

Epilepsy is a prevalent and severe neurological disorder and approximately 30% of patients
are resistant to existing medications. It is of utmost importance to develop alternative …

Pentameric ligand-gated ion channels (pLGICs), such as nicotinic acetylcholine, glycine, γ-
aminobutyric acid GABA A/C receptors, and the Gloeobacter violaceus ligand-gated ion …