Anti-cytokine autoantibodies (ACAAs) are increasingly recognized as modulating disease
severity in infection, inflammation and autoimmunity. By reducing or augmenting cytokine …

Anticytokine autoantibodies are an emerging mechanism of disease in previously healthy
adults. Patients with these syndromes demonstrate a unique infectious phenotype …

We investigated an otherwise healthy patient presenting two episodes of staphylococcal
cellulitis and abscesses, accompanied by high fever and biological signs of inflammation …

Abstract The type I IFN (IFN‐I) system is essential to limit severe viral disease in humans.
Thus, IFN‐I deficiencies are associated with serious life‐threatening infections. Remarkably …

Pharmaceutically prepared IgG, pooled from sera of over 2,000 normal individuals,
contained both monomeric and dimeric IgG. Each type of IgG bound 125I-labeled interleukin …

Cytokines are polypeptide or glycopeptide signalling molecules with molecular weights from
5 to 70,000 Daltons (Table 1). They act at extremely low concentrations (picomolar and …

An important aspect of evaluating the safety of therapeutic biologicals is the assessment of
the unwanted immunogenicity of such biologicals in recipients. Properly planned …

Autoantibodies to cytokines occur in many different conditions and situations and can cause
a wide range of disease, including pulmonary alveolar proteinosis, disseminated non …

Idiotypic determinants, antigenic sites expressed on the variable region of Ig molecules of
malignant B cells, represent tumor-specific Ags but are weak immunogens. We have …

This paper demonstrates and characterizes naturally occurring antibodies to interferon (IFN)
in human IgG preparations. In vitro neutralization of the antiviral effect of IFN alpha and IFN …