The endoplasmic reticulum (ER) is the largest intracellular organelle. It forms a complex
network of continuous sheets and tubules, extending from the nuclear envelope (NE) to the …

Abstract The Adeno-associated viruses (AAVs) are not associated with any diseases, and
their ability to package non-genomic DNA and to transduce different cell/tissue populations …

Repeated rounds of nuclear envelope (NE) rupture and repair have been observed in
laminopathy and cancer cells and result in intermittent loss of nucleus compartmentalization …

The past decade has seen a complete rethinking of the traditional view of the nuclear
envelope as simply a passive enclosure for the chromosomes. The convergence of several …

DNA viruses undertake their replication within the cell nucleus, and therefore they must first
deliver their genome into the nucleus of their host cells. Thus, trafficking across the nuclear …

Many viruses depend on nuclear proteins for replication. Therefore, their viral genome must
enter the nucleus of the host cell. In this review we briefly summarize the principles of …

The movement of proteins between the cytoplasm and the nucleus conventionally involves
the recognition of nuclear targeting signals by members of the importin (Imp) superfamily of …

Parvoviruses elaborate rugged nonenveloped icosahedral capsids of∼ 260 Å in diameter
that comprise just 60 copies of a common core structural polypeptide. While serving as …

In eukaryotic cells the nuclear genome is enclosed by the nuclear envelope (NE). In
metazoans, the NE breaks down in mitosis and it has been assumed that the physical barrier …

The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects,
regulates, and organizes the eukaryote genome and adapts to epigenetic changes and to its …