With the elucidation of myriad anabolic and catabolic enzyme-catalyzed cellular pathways
crisscrossing each other, an obvious question arose: how could these networks operate with …

The focus of this review is the human de novo purine biosynthetic pathway. The pathway
enzymes are enumerated, as well as the reactions they catalyze and their physical …

This work is devoted to the phenomenon of liquid-liquid phase separation (LLPS), which has
come to be recognized as fundamental organizing principle of living cells. We distinguish …

Abstract Inosine-5′-monophosphate dehydrogenase (IMPDH), a key regulatory enzyme in
purine nucleotide biosynthesis, dynamically assembles filaments in response to changes in …

Many metabolic enzymes self-assemble into micron-scale filaments to organize and
regulate metabolism. The appearance of these assemblies often coincides with large …

The universally conserved enzyme phosphoribosyl pyrophosphate synthetase (PRPS)
assembles filaments in evolutionarily diverse organisms. PRPS is a key regulator of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
coronavirus disease 2019 (COVID-19). The NSP15 endoribonuclease enzyme, known as …

The poly-ADP-ribosyltransferase tankyrase (TNKS, TNKS2) controls a wide range of disease-
relevant cellular processes, including WNT–β-catenin signalling, telomere length …

Inosine 5′ monophosphate dehydrogenase (IMPDH) is a critical regulatory enzyme in
purine nucleotide biosynthesis that is inhibited by the downstream product GTP. Multiple …

Carboxysomes are proteinaceous bacterial microcompartments that sequester the key
enzymes for carbon fixation in cyanobacteria and some proteobacteria. They consist of a …