Alzheimer's disease: experimental models and reality

E Drummond, T Wisniewski - Acta neuropathologica, 2017 - Springer
Experimental models of Alzheimer's disease (AD) are critical to gaining a better
understanding of pathogenesis and to assess the potential of novel therapeutic approaches …

Clearance systems in the brain—implications for Alzheimer disease

JM Tarasoff-Conway, RO Carare, RS Osorio… - Nature reviews …, 2015 - nature.com
Accumulation of toxic protein aggregates—amyloid-β (Aβ) plaques and
hyperphosphorylated tau tangles—is the pathological hallmark of Alzheimer disease (AD) …

Plasma exosomal miRNAs in persons with and without Alzheimer disease: altered expression and prospects for biomarkers

G Lugli, AM Cohen, DA Bennett, RC Shah, CJ Fields… - PloS one, 2015 - journals.plos.org
To assess the value of exosomal miRNAs as biomarkers for Alzheimer disease (AD), the
expression of microRNAs was measured in a plasma fraction enriched in exosomes by …

Immunotherapeutic approaches for Alzheimer's disease

T Wisniewski, F Goñi - Neuron, 2015 - cell.com
Alzheimer's disease (AD) is the most prevalent form of dementia worldwide and is an
emerging global epidemic. It is characterized by an imbalance between production and …

The emerging role of microRNAs in Alzheimer's disease

GD Femminella, N Ferrara, G Rengo - Frontiers in physiology, 2015 - frontiersin.org
MicroRNAs (miRNAs) are small non-coding RNA which have been shown to regulate gene
expression. The alteration ofmiRNAs expression has been associated with several …

Omega‐3 Fatty Acids in Early Prevention of Inflammatory Neurodegenerative Disease: A Focus on Alzheimer's Disease

J Thomas, CJ Thomas, J Radcliffe… - BioMed research …, 2015 - Wiley Online Library
Alzheimer's disease (AD) is the leading cause of dementia and the most common
neurodegenerative disease in the elderly. Furthermore, AD has provided the most positive …

Unraveling the complexity of human brain: Structure, function in healthy and disease states

OF Sultana, M Bandaru, MA Islam, PH Reddy - Ageing Research Reviews, 2024 - Elsevier
The human brain stands as an intricate organ, embodying a nexus of structure, function,
development, and diversity. This review delves into the multifaceted landscape of the brain …

[HTML][HTML] APOE-amyloid interaction: Therapeutic targets

T Wisniewski, E Drummond - Neurobiology of disease, 2020 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that is growing in
prevalence globally. It is the only major cause of death without any effective …

microRNA-based biomarkers in Alzheimer's disease (AD)

Y Zhao, V Jaber, PN Alexandrov, A Vergallo… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is a multifactorial, age-related neurological disease characterized
by complex pathophysiological dynamics taking place at multiple biological levels, including …

Changes in the chemical barrier composition of tears in Alzheimer's disease reveal potential tear diagnostic biomarkers

G Kalló, M Emri, Z Varga, B Ujhelyi, J Tőzsér, A Csutak… - PloS one, 2016 - journals.plos.org
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, with
increasing prevalence affecting millions of people worldwide. Currently, only autopsy is able …