Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and
experimental studies have documented that melatonin could inhibit different types of cancer …

Endoplasmic reticulum (ER) is a dynamic organelle that participates in a number of cellular
functions by controlling lipid metabolism, calcium stores, and proteostasis. Under stressful …

Intestinal diseases caused by sleep deprivation (SD) are severe public health threats
worldwide. This study focuses on the effect of melatonin on intestinal mucosal injury and …

The pineal hormone melatonin has attracted great scientific interest since its discovery in
1958. Despite the enormous number of basic and clinical studies the exact role of melatonin …

Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced
by the pineal gland, but also by other nonendocrine organs, of most mammals including …

The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

The expression of 'clock'genes occurs in all tissues, but especially in the suprachiasmatic
nuclei (SCN) of the hypothalamus, groups of neurons in the brain that regulate circadian …

Background: Hepatocellular carcinoma (HCC) growth relies on angiogenesis via vascular
endothelial growth factor (VEGF) release. Hypoxia within tumour environment leads to …

Melatonin, the major secretory product of the pineal gland, not only regulates circadian
rhythms, mood, and sleep but also has actions in neoplastic processes which are being …

Cancer is a large group of diseases and the second leading cause of death worldwide.
Lung, prostate, colorectal, stomach, and liver cancers are the most common types of cancer …