Activation of hepatic stellate cells (HSCs) constitutes a crucial etiological factor leading to
liver fibrosis. Theaflavine (TF) is a characteristic bioactive compound in fermented tea. Here …

Trans-differentiation, or activation, of hepatic stellate cells (HSCs) is a hallmark event in liver
fibrosis although the underlying mechanism is not fully appreciated. Serum response factor …

Progression of chronic kidney disease is a principal challenge in Nephrology, as effective
therapies to halt or even reverse established lesion are not available yet. While numerous …

Fibroblasts have a central role in tissue fibrosis and fibrotic diseases. Fibroblast activation is
regulated by several mechanisms including epigenetic modifications; histone modifications …

Simple Summary The tumor suppressor protein P53 is a major player in preventing liver
cancer development and progression. In this study we could show that P53 negatively …

Background Endometrial‐derived stem cells are key players in endometriosis (EMs)
pathogenesis, while the mechanism involved is still unclear. Herein, the role and regulatory …

Background Recent studies have confirmed that RASAL1 has an antitumor effect in many
cancers, but its functional role and the molecular mechanism underlying in colon cancer has …

Developmental dysplasia of the hip (DDH) is one of the most common congenital
malformations and covers a spectrum of hip disorders from mild dysplasia to irreducible …

胆道闭锁(BA) 是一种严重的婴幼儿肝胆系统疾病, 很快会进展为不可逆的肝纤维化,
最终导致肝衰竭, 威胁患儿生命. 及时有效地遏制BA 肝纤维化是延长或实现患儿自体肝生存的 …

Objectives: To measure the expression of matrix metalloproteinase (MMP)-2, tissue inhibitor
of matrix metalloproteinase inhibitor (TIMP)-2, and CD147 in mice with chronic liver injury …