What is holding back the development of antiviral metallodrugs? A literature overview and implications for SARS-CoV-2 therapeutics and future viral outbreaks

REF de Paiva, AM Neto, IA Santos, ACG Jardim… - Dalton …, 2020 - pubs.rsc.org
In light of the Covid-19 outbreak, this review brings together historical and current literature
efforts towards the development of antiviral metallodrugs. Classical compounds such as …

[HTML][HTML] A comprehensive approach to the analysis of antibiotic-metal complexes

S Ramotowska, M Wysocka, J Brzeski… - TrAC Trends in …, 2020 - Elsevier
Complexes of antibiotics with metal ions draw attention of scientists looking for new drugs as
well as those endeavoring to increase the activity of antibiotics that are currently in use. The …

Copper (II) and zinc (II) complexes with Hydrazone: Synthesis, crystal structure, Hirshfeld surface and antibacterial activity

PHO Santiago, MB Santiago, CHG Martins… - Inorganica Chimica …, 2020 - Elsevier
The present study reports the synthesis and characterization of six Cu (II) and Zn (II)
complexes with 2-cetylpyridinenicotinichydrazone (HL). The characterization of the …

Synthesis, Characterization, PXRD Studies, Theoretical Calculation, and Antitumor Potency Studies of a Novel N, O‐Multidentate Chelating Ligand and Its Zr (IV), V (IV …

HH Elganzory, SS Hassan, SA Aly… - Bioinorganic …, 2022 - Wiley Online Library
A new series of Zr (IV), V (IV), Ru (III), and Cd (II) complexes with the ligand N‐((5‐hydroxy‐4‐
oxo‐4H‐pyran‐3‐yl) methylene)‐2‐(p‐tolylamino) acetohydrazide (H2L) have been …

Synthesis, characterization, PXRD studies, and theoretical calculation of the effect of gamma irradiation and antimicrobial studies on novel Pd (II), Cu (II), and Cu (I) …

SS Hassan, SA Aly, AI Al-Sulami, SAH Albohy… - Frontiers in …, 2024 - frontiersin.org
The main objective of this study is to synthesize and characterize of a new three complexes
of Pd (II), Cu (II), and Cu (I) metal ions with novel ligand ((Z)-2-(phenylamino)-N'-(thiophen-2 …

Pseudo-tetrahedral copper (II) complex derived from N'-[(2E, 3Z)-4-hydroxy-4-phenylbut-3-en-2-ylidene] acetohydrazide: Synthesis, molecular structure, quantum …

AK Patel, RN Jadeja, H Roy, RN Patel, SK Patel… - Journal of Molecular …, 2019 - Elsevier
The mononuclear copper (II) complex involving Schiff base ligand (HL) where HL=(N'-[(2E,
3Z)-4-hydroxy-4-phenylbut-3-en-2-ylidene] acetohydraziede) was prepared and …

Synthesis, crystal structures and antibacterial properties of four complexes derived from mono-or diquinoline-substituted acylhydrazone ligands

YQ Lin, SX He, XM Tian, C Huang, DM Chen… - Inorganica Chimica …, 2022 - Elsevier
Two quinoline-substituted acylhydrazone ligands (L 1 and L 2) were synthesized from the
reaction of 2-aminobenzoylhydrazide and quinoline-8-carboxaldehyde in a molar ratio of 1 …

Transition metal complexes derived from N′‐(4‐fluorobenzylidene)‐2‐(quinolin‐2‐yloxy) acetohydrazide: Synthesis, structural characterization, and biocidal …

FA El‐saied, MME Shakdofa… - Applied …, 2020 - Wiley Online Library
Mononuclear Mn2+ and Cu2+,‐VO2+, Co2+, Ni2+,‐and Zn2+ complexes of a synthetic
novel hydrazone containing a quinoline moiety were prepared. The composition and …

Copper (II) hydrazone complexes with different nuclearities and geometries: Synthesis, structural characterization, antioxidant SOD activity and antiproliferative …

AK Patel, RN Jadeja, H Roy, RN Patel, SK Patel… - Polyhedron, 2020 - Elsevier
New copper (II) hydrazone complexes with (Z)-2-(phenyl (2-(pyridin-2-yl) hydrazono) methyl)
pyridine (L) were synthesized and characterized using various physicochemical methods …

Copper (II) complexes containing hydrazone and bipyridine/phenanthroline ligands for anticancer application against breast cancer cells

DP Dorairaj, P Kumar, H Rajasekaran… - Journal of Inorganic …, 2025 - Elsevier
In this work, mixed ligand Cu (II) complexes containing hydrazone and bipyridine ligands
(CB1-CB5), or hydrazone and phenanthroline ligands (CP1-CP5) have been synthesized …