In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

Toll‐like receptors (TLRs) are germline‐encoded receptors that are central to innate and
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …

Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune rheumatic disease
characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands, whereby …

Autoimmune diseases are immune disorders characterized by T cell hyperactivity and B cell
overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of …

Autoimmune diseases are a family of chronic systemic inflammatory disorders, characterized
by the dysregulation of the immune system which finally results in the break of tolerance to …

Primary Sjögren syndrome (pSS) is a progressive autoimmune disease characterized by
sicca and systemic manifestations. In this Review, we summarize the available data on …

Recently recognized as a distinct CD4+ T helper (Th) lineage, Th17 cells have been
implicated in host responses to infections and in pathogenesis associated with autoimmune …

Sjögren's syndrome (SjS) is a systemic autoimmune disease, characterized by the presence
of periductal lymphocytic infiltrations in salivary and lachrymal glands resulting in oral and …

Human interleukin (IL) 1 receptor–associated kinase 4 (IRAK-4) deficiency is a recently
discovered primary immunodeficiency that impairs Toll/IL-1R immunity, except for the Toll …

Sjögren's syndrome (SS) or autoimmune epithelitis is a prototype autoimmune disorder with
unique features: a broad clinical spectrum that extends from local exocrinopathy to systemic …