Synaptic GluN2A-containing NMDA receptors: from physiology to pathological synaptic plasticity
L Franchini, N Carrano, M Di Luca… - International journal of …, 2020 - mdpi.com
N-Methyl-d-Aspartate Receptors (NMDARs) are ionotropic glutamate-gated receptors.
NMDARs are tetramers composed by several homologous subunits of GluN1-, GluN2-, or …
NMDARs are tetramers composed by several homologous subunits of GluN1-, GluN2-, or …
NMDA receptors as therapeutic targets for depression treatment: Evidence from clinical to basic research
S Lv, K Yao, Y Zhang, S Zhu - Neuropharmacology, 2023 - Elsevier
Ketamine, functioning as a channel blocker of the excitatory glutamate-gated N-methyl-d-
aspartate (NMDA) receptors, displays compelling fast-acting and sustained antidepressant …
aspartate (NMDA) receptors, displays compelling fast-acting and sustained antidepressant …
Interactions among brain-derived neurotrophic factor and neuroimmune pathways are key components of the major psychiatric disorders
N Mehterov, D Minchev, M Gevezova, V Sarafian… - Molecular …, 2022 - Springer
The purpose of this review is to summarize the current knowledge regarding the reciprocal
associations between brain-derived neurotrophic factor (BDNF) and immune-inflammatory …
associations between brain-derived neurotrophic factor (BDNF) and immune-inflammatory …
[HTML][HTML] Chemogenetic activation of the HPC-mPFC pathway improves cognitive dysfunction in lipopolysaccharide-induced brain injury
C Ge, W Chen, L Zhang, Y Ai, Y Zou, Q Peng - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: Although sepsis-associated encephalopathy (SAE) is a common psychiatric
complication in septic patients, the underlying mechanisms remain unclear. Here, we …
complication in septic patients, the underlying mechanisms remain unclear. Here, we …
Testing the role of glutamate NMDA receptors in peripheral trigeminal nociception implicated in migraine pain
C Guerrero-Toro, K Koroleva, E Ermakova… - International Journal of …, 2022 - mdpi.com
The pro-nociceptive role of glutamate in the CNS in migraine pathophysiology is well
established. Glutamate, released from trigeminal afferents, activates second order …
established. Glutamate, released from trigeminal afferents, activates second order …
Post-inflammatory behavioural despair in male mice is associated with reduced cortical glutamate-glutamine ratios, and circulating lipid and energy metabolites
Post-inflammatory behaviours in rodents are widely used to model human depression and to
test the efficacy of novel anti-depressants. Mice injected with lipopolysaccharide (LPS) …
test the efficacy of novel anti-depressants. Mice injected with lipopolysaccharide (LPS) …
Targeting NMDA receptors in emotional disorders: their role in neuroprotection
S Wang, L Bian, Y Yin, J Guo - Brain Sciences, 2022 - mdpi.com
Excitatory glutamatergic neurotransmission mediated through N-methyl-D-Aspartate
(NMDA) receptors (NMDARs) is essential for synaptic plasticity and neuronal survival. While …
(NMDA) receptors (NMDARs) is essential for synaptic plasticity and neuronal survival. While …
Intermittent systemic exposure to lipopolysaccharide-induced inflammation disrupts hippocampal long-term potentiation and impairs cognition in aging male mice
EB Engler-Chiurazzi, AE Russell, JM Povroznik… - Brain, behavior, and …, 2023 - Elsevier
Age-related cognitive decline, a common component of the brain aging process, is
associated with significant impairment in daily functioning and quality of life among geriatric …
associated with significant impairment in daily functioning and quality of life among geriatric …
Acute sleep deprivation-induced anxiety and disruption of hypothalamic cell survival and plasticity: a mechanistic study of protection by butanol extract of Tinospora …
P Bajaj, G Kaur - Neurochemical Research, 2022 - Springer
Since sleep is a key homeostatic phenomenon of the body, therefore understanding the
complex etiology of the neurological outcome of sleep deprivation (SD) such as anxiety …
complex etiology of the neurological outcome of sleep deprivation (SD) such as anxiety …
Anti-Inflammatory Activity of N-Docosahexaenoylethanolamine and N-Eicosapentaenoylethanolamine in a Mouse Model of Lipopolysaccharide-Induced …
A Tyrtyshnaia, S Konovalova, A Bondar… - International Journal of …, 2021 - mdpi.com
The search for methods of cognitive impairment treatment and prevention in neurological
and neurodegenerative diseases is an urgent task of modern neurobiology. It is now known …
and neurodegenerative diseases is an urgent task of modern neurobiology. It is now known …