Choreography of bacteriophage T7 DNA replication
SJ Lee, CC Richardson - Current opinion in chemical biology, 2011 - Elsevier
The replication system of phage T7 provides a model for DNA replication. Biochemical,
structural, and single-molecule analyses together provide insight into replisome mechanics …
structural, and single-molecule analyses together provide insight into replisome mechanics …
Impact of macromolecular crowding on DNA replication
Enzymatic activities in vivo occur in a crowded environment composed of many
macromolecules. This environment influences DNA replication by increasing the …
macromolecules. This environment influences DNA replication by increasing the …
Molecular basis for the initiation of DNA primer synthesis
During the initiation of DNA replication, oligonucleotide primers are synthesized de novo by
primases and are subsequently extended by replicative polymerases to complete genome …
primases and are subsequently extended by replicative polymerases to complete genome …
DnaG primase—A target for the development of novel antibacterial agents
The bacterial primase—an essential component in the replisome—is a promising but
underexploited target for novel antibiotic drugs. Bacterial primases have a markedly different …
underexploited target for novel antibiotic drugs. Bacterial primases have a markedly different …
Insight into the human DNA primase interaction with template-primer
AG Baranovskiy, Y Zhang, Y Suwa, J Gu… - Journal of Biological …, 2016 - ASBMB
DNA replication in almost all organisms depends on the activity of DNA primase, a DNA-
dependent RNA polymerase that synthesizes short RNA primers of defined size for DNA …
dependent RNA polymerase that synthesizes short RNA primers of defined size for DNA …
Bi-and multi-directional gene transfer in the natural populations of polyvalent bacteriophages, and their host species spectrum representing foodborne versus other …
E Gabashvili, S Kobakhidze, S Koulouris… - Food and Environmental …, 2021 - Springer
Unraveling the trends of phage-host versus phage-phage coevolution is critical for avoiding
possible undesirable outcomes from the use of phage preparations intended for therapeutic …
possible undesirable outcomes from the use of phage preparations intended for therapeutic …
Definition of the binding specificity of the T7 bacteriophage primase by analysis of a protein binding microarray using a thermodynamic model
G Lipps - Nucleic Acids Research, 2024 - academic.oup.com
Protein binding microarrays (PBM), SELEX, RNAcompete and chromatin-
immunoprecipitation have been intensively used to determine the specificity of nucleic acid …
immunoprecipitation have been intensively used to determine the specificity of nucleic acid …
Plant organellar DNA primase-helicase synthesizes RNA primers for organellar DNA polymerases using a unique recognition sequence
A Peralta-Castro, N Baruch-Torres… - Nucleic acids …, 2017 - academic.oup.com
DNA primases recognize single-stranded DNA (ssDNA) sequences to synthesize RNA
primers during lagging-strand replication. Arabidopsis thaliana encodes an ortholog of the …
primers during lagging-strand replication. Arabidopsis thaliana encodes an ortholog of the …
Development of potential broad spectrum antimicrobials using C2-symmetric 9-fluorenone alkyl amine
S Choi, MA Larson, SH Hinrichs… - Bioorganic & medicinal …, 2016 - Elsevier
DNA-dependent RNA primase is essential for de novo primer synthesis during DNA
replication in all living organisms. Bacterial DnaG primase is an attractive target for inhibition …
replication in all living organisms. Bacterial DnaG primase is an attractive target for inhibition …
The N-terminal domain of the Drosophila mitochondrial replicative DNA helicase contains an iron-sulfur cluster and binds DNA
The metazoan mitochondrial DNA helicase is an integral part of the minimal mitochondrial
replisome. It exhibits strong sequence homology with the bacteriophage T7 gene 4 protein …
replisome. It exhibits strong sequence homology with the bacteriophage T7 gene 4 protein …