Antibodies to combat viral infections: development strategies and progress

G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

Emerging concepts and technologies in vaccine development

M Brisse, SM Vrba, N Kirk, Y Liang, H Ly - Frontiers in immunology, 2020 - frontiersin.org
Despite the success of vaccination to greatly mitigate or eliminate threat of diseases caused
by pathogens, there are still known diseases and emerging pathogens for which the …

Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design

R Rappuoli, MJ Bottomley, U D'Oro, O Finco… - Journal of Experimental …, 2016 - rupress.org
Traditionally, vaccines have been developed by cultivating infectious agents and isolating
the inactivated whole pathogen or some of its purified components. 20 years ago, reverse …

Advances in gene-based vaccine platforms to address the COVID-19 pandemic

D Pushparajah, S Jimenez, S Wong, H Alattas… - Advanced drug delivery …, 2021 - Elsevier
The novel betacoronavirus, SARS-CoV-2 (severe acute respiratory syndrome coronavirus
2), has spread across the globe at an unprecedented rate since its first emergence in Wuhan …

Changing priorities in vaccinology: antibiotic resistance moving to the top

A Tagliabue, R Rappuoli - Frontiers in immunology, 2018 - frontiersin.org
Antimicrobial resistance (AMR) is currently the most alarming issue for human health. AMR
already causes 700,000 deaths/year. It is estimated that 10 million deaths due to AMR will …

Vaccine development: Current trends and technologies

R Poria, D Kala, R Nagraik, Y Dhir, S Dhir, B Singh… - Life Sciences, 2024 - Elsevier
Despite the effectiveness of vaccination in reducing or eradicating diseases caused by
pathogens, there remain certain diseases and emerging infections for which developing …

Synthetic biology for bioengineering virus‐like particle vaccines

HK Charlton Hume, J Vidigal… - Biotechnology and …, 2019 - Wiley Online Library
Vaccination is the most effective method of disease prevention and control. Many viruses
and bacteria that once caused catastrophic pandemics (eg, smallpox, poliomyelitis …

Use of plant viruses and virus-like particles for the creation of novel vaccines

I Balke, A Zeltins - Advanced drug delivery reviews, 2019 - Elsevier
In recent decades, the development of plant virology and genetic engineering techniques
has resulted in the construction of plant virus-based vaccines for protection against different …

[HTML][HTML] Computational design of vaccine immunogens

KM Castro, A Scheck, S Xiao, BE Correia - Current opinion in …, 2022 - Elsevier
Computational protein engineering has enabled the rational design of customized proteins,
which has propelled both sequence-based and structure-based immunogen engineering …

[HTML][HTML] SARS-CoV-2 vaccine research and development: conventional vaccines and biomimetic nanotechnology strategies

L Huang, Y Rong, Q Pan, K Yi, X Tang, Q Zhang… - Asian journal of …, 2021 - Elsevier
The development of a massively producible vaccine against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, is essential for stopping the …