Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

Resident memory T (Trm) cells stably occupy tissues and cannot be sampled in superficial
venous blood. Trm cells are heterogeneous but collectively constitute the most abundant …

CD8+ tumor-infiltrating lymphocytes with a tissue-resident memory T (T RM) cell phenotype
are associated with favorable prognosis in patients with triple-negative breast cancer …

The immune system can suppress tumour development both by eliminating malignant cells
and by preventing the outgrowth and spread of cancer cells that resist eradication. Clinical …

Purpose: Therapeutic blockade of immune checkpoints has revolutionized cancer treatment.
Durable responses, however, occur in less than half of those treated, and efforts to improve …

Background & Aims The pathogenesis of immune checkpoint inhibitor (ICI)–colitis remains
incompletely understood. We sought to identify key cellular drivers of ICI-colitis and their …

The presence of tumour-infiltrating lymphocytes (TILs) is associated with favourable
outcomes in patients with breast cancer as well as in those with other solid tumours. T cells …

CD8+ T lymphocytes are the major anti-tumor effector cells. Most cancer immunotherapeutic
approaches seek to amplify cytotoxic T lymphocytes (CTL) specific to malignant cells. A …

Tissue-resident memory CD8+ T (Trm) cells mediate potent local innate and adaptive
immune responses and play a central role against solid tumors. However, whether Trm cells …

Immune responses in tissues are constrained by the physiological properties of the tissue
involved. Tissue-resident memory T cells (TRM cells) are a recently discovered lineage of T …