Membrane proteins are attractive targets for monoclonal antibody (mAb) discovery and
development. Although several approved mAbs against membrane proteins have been …

Ferroptosis is a novel regulatory cell death, which is characterized by iron dependency and
mainly caused by accumulation of intracellular lipid peroxides and reactive oxygen species …

The redirection of T cell activity using bispecific antibodies is one of the most promising
cancer immunotherapy approaches currently in development, but it is limited by cytokine …

Breast cancer remains the leading cause of cancer-related death among women worldwide,
and its incidence is also increasing. High recurrence rate and metastasis rate are the key …

Yeast surface display has proven to be an effective tool in the discovery and evolution of
ligands with new or improved binding activity. Selections for binding activity are generally …

Despite rapid advances in diagnostic and treatment approaches, the overall survival rate of
cancer has not been improved. Colorectal cancer (CRC) is recognized as the third leading …

T cell-redirecting strategies have emerged as effective cancer immunotherapy approaches.
Bispecific antibodies (bsAbs) are designed to specifically recruit T cells to the tumor …

The recruitment of T-cells by bispecific antibodies secreted from adoptively transferred, gene-
modified autologous cells has shown satisfactory results in preclinical cancer models. Even …

Phages or bacteriophages, viruses that infect and replicate inside bacteria, are the most
abundant microorganisms on earth. The realization that antibiotic resistance poses a …

Background Redirecting T cells to tumor cells using bispecific antibodies (BsAbs) is
emerging as a potent cancer therapy. The main concept of this strategy is to cross-link tumor …