Modulation of metabolic detoxification pathways using foods and food‐derived components: a scientific review with clinical application

RE Hodges, DM Minich - Journal of nutrition and metabolism, 2015 - Wiley Online Library
Research into human biotransformation and elimination systems continues to evolve.
Various clinical and in vivo studies have been undertaken to evaluate the effects of foods …

Ellagic acid: Pharmacological activities and molecular mechanisms involved in liver protection

WR García-Niño, C Zazueta - Pharmacological Research, 2015 - Elsevier
Traditional drugs or therapies rarely have effects on regression of chronic liver diseases,
which result in many cases from sustained oxidative stress. In recent years, ellagic acid (EA) …

Medicinal plants used against hepatic disorders in Bangladesh: a comprehensive review

R Das, S Mitra, AM Tareq, TB Emran… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Liver disease is a major cause of illness and death
worldwide which accounts for approximately 2 million deaths per year worldwide, 1 million …

Ellagic acid protects against non-alcoholic fatty liver disease in streptozotocin-diabetic rats by activating AMPK

JZ ALTamimi, GM Alshammari, NA AlFaris… - Pharmaceutical …, 2022 - Taylor & Francis
Context Ellagic acid (EA) is used in traditional medicine to treated hyperlipidaemia.
Objective This study examined if AMPK mediates the anti-steatotic effect of ellagic acid (EA) …

A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives

R Domitrović, I Potočnjak - Archives of toxicology, 2016 - Springer
Hepatoprotective effects of natural compounds have been frequently attributed to their
antioxidant properties and the ability to mobilize endogenous antioxidant defense system …

Role of ellagic acid for the prevention and treatment of liver diseases

V Aishwarya, S Solaipriya… - Phytotherapy …, 2021 - Wiley Online Library
Globally, one of the alarming problems is the prevalence and burden of liver diseases,
which accounts for 2 million cases per year. Chronic liver aetiologies such as hepatitis …

Herb–drug interaction studies of herbs used in treatment of cardiovascular disorders—A narrative review of preclinical and clinical studies

AS Shaikh, AB Thomas, SS Chitlange - Phytotherapy research, 2020 - Wiley Online Library
About 70% of the world population is currently using medicinal herbs as complementary or
alternative medicine, which is increasing at a tremendous pace in both developed and …

[HTML][HTML] Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress

YE Cho, BJ Song - Redox biology, 2018 - Elsevier
Alcoholic liver disease (ALD) is a major chronic liver disease worldwide and can range from
simple steatosis, inflammation to fibrosis/cirrhosis possibly through leaky gut and systemic …

Ellagic acid mitigates sodium arsenite-induced renal and hepatic toxicity in male Wistar rats

S Mehrzadi, I Fatemi, AR Malayeri, A Khodadadi… - Pharmacological …, 2018 - Springer
Background The aim of this study was to investigate the effect of ellagic acid (EA) on arsenic-
induced renal and hepatic toxicity in rats. Methods A total number of 35 male Wistar rats …

[HTML][HTML] Phytochemical-mediated modulation of signaling pathways: A promising avenue for drug discovery

JK Paul, M Azmal, ANMSNB Haque… - Advances in Redox …, 2024 - Elsevier
Phytochemicals are bioactive compounds derived from plants, renowned for their
therapeutic potential. This study explores their pivotal roles in therapy and drug …