Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining

CY Chiang, M Ohashi, Y Tang - Natural product reports, 2023 - pubs.rsc.org
Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

[HTML][HTML] Developing fungal heterologous expression platforms to explore and improve the production of natural products from fungal biodiversity

X Meng, Y Fang, M Ding, Y Zhang, K Jia, Z Li… - Biotechnology …, 2022 - Elsevier
Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

Cannabis sativa: origin and history, glandular trichome development, and cannabinoid biosynthesis

Z Xie, Y Mi, L Kong, M Gao, S Chen… - Horticulture …, 2023 - academic.oup.com
Is Cannabis a boon or bane? Cannabis sativa has long been a versatile crop for fiber
extraction (industrial hemp), traditional Chinese medicine (hemp seeds), and recreational …

The expanding CRISPR toolbox for natural product discovery and engineering in filamentous fungi

C Woodcraft, YH Chooi, I Roux - Natural Product Reports, 2023 - pubs.rsc.org
Covering: up to May 2022 Fungal genetics has transformed natural product research by
enabling the elucidation of cryptic metabolites and biosynthetic steps. The enhanced …

How to completely squeeze a fungus—advanced genome mining tools for novel bioactive substances

A Schüller, L Studt-Reinhold, J Strauss - Pharmaceutics, 2022 - mdpi.com
Fungal species have the capability of producing an overwhelming diversity of bioactive
substances that can have beneficial but also detrimental effects on human health. These so …

Dual cytoplasmic‐peroxisomal compartmentalization engineering and multiple metabolic engineering strategies for high yield non‐psychoactive cannabinoid in …

Y Ding, Y Ning, D Xin, Y Fu - Biotechnology Journal, 2024 - Wiley Online Library
CBG (Cannabigerol), a nonpsychoactive cannabinoid, has garnered attention due to its
extensive antimicrobial and anti‐inflammatory properties. However, the natural content of …

Engineering cannabinoid production in Saccharomyces cerevisiae

C Schmidt, M Aras, O Kayser - Biotechnology Journal, 2024 - Wiley Online Library
Phytocannabinoids are natural products with highly interesting pharmacological properties
mainly produced by plants. The production of cannabinoids in a heterologous host system …

Bioengineering of the Marine Diatom Phaeodactylum tricornutum with Cannabis Genes Enables the Production of the Cannabinoid Precursor, Olivetolic Acid

F Awwad, EI Fantino, M Héneault… - International Journal of …, 2023 - mdpi.com
The increasing demand for novel natural compounds has prompted the exploration of
innovative approaches in bioengineering. This study investigates the bioengineering …

Scale-up of an amoeba-based process for the production of the cannabinoid precursor olivetolic acid

JE Kufs, C Reimer, E Steyer, V Valiante… - Microbial Cell …, 2022 - Springer
Background The availability of new biological platform organisms to get access to innovative
products and processes is fundamental for the progress in biotechnology and bioeconomy …

Mining an O-methyltransferase for de novo biosynthesis of physcion in Aspergillus nidulans

Y Yao, EL Yang, Y Pan, X Shu, G Liu - Applied Microbiology and …, 2023 - Springer
Physcion is one of natural anthraquinones, registered as a novel plant-derived fungicide
due to its excellent prevention of plant disease. However, the current production of physcion …