An insight on medicinal attributes of 1, 2, 4-triazoles
R Aggarwal, G Sumran - European journal of medicinal chemistry, 2020 - Elsevier
The present review aims to summarize the pharmacological profile of 1, 2, 4-triazole, one of
the emerging privileged scaffold, as antifungal, antibacterial, anticancer, anticonvulsant …
the emerging privileged scaffold, as antifungal, antibacterial, anticancer, anticonvulsant …
Recent developments on triazole nucleus in anticonvulsant compounds: a review
MX Song, XQ Deng - Journal of enzyme inhibition and medicinal …, 2018 - Taylor & Francis
Epilepsy is one of the common diseases seriously threatening life and health of human.
More than 50 million people are suffering from this condition and anticonvulsant agents are …
More than 50 million people are suffering from this condition and anticonvulsant agents are …
Investigation of the binding interaction between estazolam and bovine serum albumin: multi-spectroscopic methods and molecular docking technique
YF Zhang, KL Zhou, YY Lou, D Pan… - Journal of Biomolecular …, 2017 - Taylor & Francis
Estazolam (Figure S1 (a)), is one of the representative of the triazolobenzodiazepine drugs
that acts on the central nervous system, mainly prescribed as a sedative and hypnotic agent …
that acts on the central nervous system, mainly prescribed as a sedative and hypnotic agent …
Constructing Nitrogen Self-Doped Covalent Triazine-Based Frameworks for Visible-Light-Driven Photocatalytic Conversion of CO2 into CH4
Photocatalytic reduction of carbon dioxide to hydrocarbon fuel provides a sustainable
strategy for addressing the increasing energy crisis as well as alleviating the greenhouse …
strategy for addressing the increasing energy crisis as well as alleviating the greenhouse …
The importance of triazole scaffold in the development of anticonvulsant agents
A Ayati, S Emami, A Foroumadi - European journal of medicinal chemistry, 2016 - Elsevier
Epilepsy is one of the most important neurological disorders with high prevalence
worldwide. Many epileptic patients are not completely treated with available drugs and need …
worldwide. Many epileptic patients are not completely treated with available drugs and need …
Design, synthesis, pharmacological evaluation, and docking study of new acridone-based 1, 2, 4-oxadiazoles as potential anticonvulsant agents
M Mohammadi-Khanaposhtani, M Shabani… - European journal of …, 2016 - Elsevier
A number of acridone-based oxadiazoles 11a–n have been synthesized and evaluated for
their anticonvulsant activity against pentylenetetrazole (PTZ)-and maximal electroshock …
their anticonvulsant activity against pentylenetetrazole (PTZ)-and maximal electroshock …
Synthesis of 1, 3, 4-oxadiazole derivatives with anticonvulsant activity and their binding to the GABAA receptor
S Wang, H Liu, X Wang, K Lei, G Li, J Li, R Liu… - European Journal of …, 2020 - Elsevier
In this study, a series of 1, 3, 4-oxadiazole derivatives (5a-s, 10a-s, and 16a-d) were
designed and synthesized using maximal electroshock (MES) and subcutaneous …
designed and synthesized using maximal electroshock (MES) and subcutaneous …
Biological activities of [1,2,4]triazolo[1,5-a]pyrimidines and analogs
S Pinheiro, EMC Pinheiro, EMF Muri… - Medicinal Chemistry …, 2020 - Springer
Abstract The [1, 2, 4] triazolo [1, 5-a] pyrimidines (TPs) comprise an important class of non-
naturally occurring small molecules that aroused the interest of researches. This scaffold is …
naturally occurring small molecules that aroused the interest of researches. This scaffold is …
A comprehensive review on triazole based conjugates as acetylcholinesterase inhibitors: Design strategies, synthesis, biological activity, structure activity …
Significant advancements have been made in development of Acetylcholinesterase
inhibitors as Anti-Alzheimer drugs. Triazoles, a 5-membered heterocyclic nucleus containing …
inhibitors as Anti-Alzheimer drugs. Triazoles, a 5-membered heterocyclic nucleus containing …
Hybridization of the effective pharmacophores for treatment of epilepsy: design, synthesis, in vivo anticonvulsant activity, and in silico studies of phenoxyphenyl-1, 3, 4 …
A Fakhrioliaei, F Abedinifar, P Salehi Darjani… - BMC chemistry, 2023 - Springer
Background Epilepsy is a common neurological disorder. The available drugs for this
disease only control convulsions in nearly 70% of patients, while bearing many side effects …
disease only control convulsions in nearly 70% of patients, while bearing many side effects …