CD73 is a novel immune checkpoint associated with adenosine metabolism that promotes
tumor progression by suppressing antitumor immune response and promoting …

The enzymes of both de novo and salvage pathways for purine nucleotide synthesis are
regulated to meet the demand of nucleic acid precursors during proliferation. Among them …

Objective Adenosine deaminase (ADA) plays an important role in immune response, which
includes two isoenzymes: ADA1 and ADA2. This study aims to explore the roles of ADA1 …

Background In the era of immunotherapy, predictive or prognostic biomarkers for head and
neck squamous cell carcinoma (HNSCC) are urgently needed. Metabolic reprogramming in …

Syzigium cumini (L.) Skeels from the Myrtaceae family is among the most common medicinal
plants used to treat diabetes in Brazil. Leaves, fruits, and barks of S. cumini have been used …

The human genome is diploid, and knowledge of the variants on each chromosome is
important for the interpretation of genomic information. Here we report the assembly of a …

Purinergic signaling through adenosine plays a key role in immune regulation. Hypoxia-
driven accumulation of extracellular adenosine results in the generation of an …

Extracellular adenosine in tumors can suppress immune responses and promote tumor
growth. Adenosine deaminase 2 (ADA2) converts adenosine into inosine. The role of ADA2 …

Simple Summary Immunotherapy leads to highly variable responses in lung cancer patients.
We assessed the value of a blood-based test to predict which patients would benefit from …

The activity of a cell‐surface ecto‐adenosine deaminase (eADA) is markedly increased in
the endothelial activation and vascular inflammation leading to decreased adenosine …