Runs of homozygosity: current knowledge and applications in livestock

E Peripolli, DP Munari, M Silva, ALF Lima… - Animal …, 2017 - Wiley Online Library
This review presents a broader approach to the implementation and study of runs of
homozygosity (ROH) in animal populations, focusing on identifying and characterizing ROH …

Inbreeding depression in livestock species: review and meta‐analysis

G Leroy - Animal genetics, 2014 - Wiley Online Library
Inbreeding, by virtue of its consequence on traits of interest, is a topic of major interest for
geneticists and animal breeders. Based on meta‐analysis conducted on 57 studies and …

Analysis of runs of homozygosity and their relationship with inbreeding in five cattle breeds farmed in Italy

G Marras, G Gaspa, S Sorbolini, C Dimauro… - Animal …, 2015 - Wiley Online Library
Increased inbreeding is an inevitable consequence of selection in livestock populations. The
analysis of high‐density single nucleotide polymorphisms (SNPs) facilitates the identification …

[HTML][HTML] Changes in genetic trends in US dairy cattle since the implementation of genomic selection

FL Guinan, GR Wiggans, HD Norman, JW Dürr… - Journal of dairy …, 2023 - Elsevier
Genomic selection increases accuracy and decreases generation interval, accelerating
genetic changes in populations. Assumptions of genetic improvement must be addressed to …

Estimation of inbreeding using pedigree, 50k SNP chip genotypes and full sequence data in three cattle breeds

Q Zhang, MPL Calus, B Guldbrandtsen, MS Lund… - BMC genetics, 2015 - Springer
Background Levels of inbreeding in cattle populations have increased in the past due to the
use of a limited number of bulls for artificial insemination. High levels of inbreeding lead to …

Runs of homozygosity and distribution of functional variants in the cattle genome

Q Zhang, B Guldbrandtsen, M Bosse, MS Lund… - BMC genomics, 2015 - Springer
Background Recent developments in sequencing technology have facilitated widespread
investigations of genomic variants, including continuous stretches of homozygous genomic …

Improving the estimation of realized effective population sizes in farm animals

JP Gutiérrez, I Cervantes… - Journal of Animal …, 2009 - Wiley Online Library
Computation of inbreeding rate (ΔF) must consider that inbreeding is delayed with one
generation with respect to the idealized population when addressed using individual …

[HTML][HTML] How genomic selection has increased rates of genetic gain and inbreeding in the Australian national herd, genomic information nucleus, and bulls

BA Scott, M Haile-Mariam, BG Cocks, JE Pryce - Journal of Dairy Science, 2021 - Elsevier
Genomic selection has been commonly used for selection for over a decade. In this time, the
rate of genetic gain has more than doubled in some countries, while inbreeding per year has …

Individual increase in inbreeding allows estimating effective sizes from pedigrees

JP Gutiérrez, I Cervantes, A Molina… - Genetics selection …, 2008 - gse-journal.org
We present here a simple approach to obtain reliable estimates of the effective population
size in real world populations via the computation of the increase in inbreeding for each …

Estimation of effective population size from the rate of coancestry in pedigreed populations

I Cervantes, F Goyache, A Molina… - Journal of animal …, 2011 - Wiley Online Library
We introduce a simple method to estimate effective population size from increase in
coancestry (Δcjk) for all pairs of individuals j and k in a reference subpopulation. An increase …