Abstract iron overload in β-thalassemia major occurs mainly due to blood transfusion, an
essential treatment for β-thalassemia major patients, which results in oxidative stress. it has …

BACKGROUND & AIMS: Classical ferroportin disease is characterized by hyperferritinemia,
normal transferrin saturation, and iron overload in macrophages. A non-classical form is …

The availability of a facile treatment for hemochromatosis renders early diagnosis of iron
overload syndromes mandatory, and in many instances genetic testing allows identification …

Erin A. Osterholm, MD, and Michael K. Georgieff, MD Iron is an essential component of
almost all biological systems. It is required for energy production, oxygen transport and use …

Sophisticated mechanisms maintain body iron homeostasis and control uptake of dietary
iron and its mobilization from stores, in order to satisfy erythropoietic needs and to recycle …

Hereditary hemochromatosis is a disorder of iron metabolism characterized by increased
iron intake and progressive storage and is related to mutations in the HFE gene. Interactions …

Serum ferritin is a useful monitoring tool for iron overload in thalassemia major. In resource
poor settings access to modalities for assessment of iron overload are limited. This study …

A hemocromatose hereditária (HH) é a mais comum doença autossômica em caucasianos e
caracteriza-se pelo aumento da absorção intestinal de ferro, o qual resulta em acúmulo …

Iron overload is a well-documented complication in thalassemia intermedia. Moreover, it is
seen that the number of blood transfusions received does not correlate with the degree of …

Co-inheritance of mutations in the HFE gene underlying hereditary hemocromatosis (HH)
may play a role in the variability of iron status in patients with β-thalassemia (β-thal) minor …