Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis

T Hamada, M Torikai, A Kuwazuru… - Arthritis & …, 2008 - Wiley Online Library
Objective Tissue hypoxia is closely associated with arthritis pathogenesis, and extracellular
high mobility group box chromosomal protein 1 (HMGB‐1) released from injured cells also …

Synthesis and in vitro antitumor activity of novel scopoletin derivatives

W Liu, J Hua, J Zhou, H Zhang, H Zhu, Y Cheng… - Bioorganic & medicinal …, 2012 - Elsevier
Twenty scopoletin derivatives were developed by a systematic combinatorial chemical
approach and their chemical structures were confirmed by MS, IR, 1H NMR spectra and …

Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress

D Bian, M Liu, Y Li, Y Xia, Z Gong… - Journal of biochemical …, 2012 - Wiley Online Library
This study aimed to investigate the effect of madecassoside against oxidative stress‐
induced injury of endothelial cells. Hydrogen peroxide (H2O2, 500 µmol/L) was employed …

Induction of apoptosis and differentiation by atractylenolide-1 isolated from Atractylodes macrocephala in human leukemia cells

HL Huang, TW Lin, YL Huang, RL Huang - Bioorganic & medicinal …, 2016 - Elsevier
Atractylodes macrocephula Koidz (A. macrocephula, also known as Baizhu) is an important
ingredient in several traditional Chinese herb complexes for the treatment of abdominal pain …

Nanocurcumin as a novel stimulator of megakaryopoiesis that ameliorates chemotherapy-induced thrombocytopenia in mice

SSM Farsani, M Sadeghizadeh, MA Gholampour… - Life Sciences, 2020 - Elsevier
Aims Platelet production improvement can resolve concerns about the limitations of external
platelet supply and platelet transfusion in thrombocytopenia patients. To this end, scientists …

Resveratrol induces human K562 cell apoptosis, erythroid differentiation, and autophagy

HW Yan, WX Hu, JY Zhang, Y Wang, K Xia, MY Peng… - Tumor Biology, 2014 - Springer
Resveratrol (Res) is a naturally occurring phytoalexin with apoptotic and inducing-glob
effects in leukemic cells, but the potential induction of erythroid differentiation in cells is not …

Norisoboldine induces apoptosis of fibroblast-like synoviocytes from adjuvant-induced arthritis rats

Y Luo, Z Wei, G Chou, Z Wang, Y Xia, Y Dai - International …, 2014 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by pronounced
synovial inflammation and hyperplasia, in which there may be an imbalance between the …

Scopoletin induces apoptosis of fibroblast‐like synoviocytes from adjuvant arthritis rats by a mitochondrial‐dependent pathway

Y Li, Y Dai, M Liu, R Pan, Y Luo… - Drug Development …, 2009 - Wiley Online Library
Scopoletin is a naturally occurring coumarin compound found in many medicinal plants,
such as Erycibe obtusifolia Benth and Aster tataricus. Our previous studies have …

High-Level Genomic Integration, Epigenetic Changes, and Expression of Sleeping Beauty Transgene

J Zhu, CW Park, L Sjeklocha, BT Kren, CJ Steer - Biochemistry, 2010 - ACS Publications
Sleeping Beauty transposon (SB-Tn) has emerged as an important nonviral vector for
integrating transgenes into mammalian genomes. We report here a novel dual fluorescent …

Involvement of ERK/MAPK pathway in megakaryocytic differentiation of K562 cells induced by 3-hydrogenkwadaphnin

A Meshkini, R Yazdanparast - Toxicology in vitro, 2008 - Elsevier
Since differentiation-induction therapy represents an attractive strategy for treatment of a
wide range of malignancies, universal efforts have been devoted to find new and potent …