The noncanonical pathway for in vivo nitric oxide generation: the nitrate-nitrite-nitric oxide pathway

V Kapil, RS Khambata, DA Jones, K Rathod… - Pharmacological …, 2020 - ASPET
In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

Metals, toxicity and oxidative stress

M Valko, H Morris, MTD Cronin - Current medicinal chemistry, 2005 - ingentaconnect.com
Metal-induced toxicity and carcinogenicity, with an emphasis on the generation and role of
reactive oxygen and nitrogen species, is reviewed. Metal-mediated formation of free radicals …

Nitrate as a potential prebiotic for the oral microbiome

BT Rosier, E Buetas, EM Moya-Gonzalvez, A Artacho… - Scientific reports, 2020 - nature.com
The salivary glands actively concentrate plasma nitrate, leading to high salivary nitrate
concentrations (5–8 mM) after a nitrate-rich vegetable meal. Nitrate is an ecological factor …

Electrical conductivity of nutrient solution influenced photosynthesis, quality, and antioxidant enzyme activity of pakchoi (Brassica campestris L. ssp. Chinensis) in a …

X Ding, Y Jiang, H Zhao, D Guo, L He, F Liu, Q Zhou… - PloS one, 2018 - journals.plos.org
To find an electrical conductivity (EC) in the nutrient solution used for pakchoi (Brassica
campestris L. ssp. Chinensis) cultivation that optimizes the plant's physiology, growth, and …

Biomarkers of oxidative damage in human disease

I Dalle-Donne, R Rossi, R Colombo… - Clinical …, 2006 - academic.oup.com
Oxidative/nitrosative stress, a pervasive condition of increased amounts of reactive
oxygen/nitrogen species, is now recognized to be a prominent feature of many acute and …

Nitrate in vegetables: toxicity, content, intake and EC regulation

P Santamaria - Journal of the Science of Food and Agriculture, 2006 - Wiley Online Library
Nitrate content is an important quality characteristic of vegetables. Vegetable nitrate content
is of interest to governments and regulators owing to the possible implications for health and …

Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate‐nitrite‐nitric oxide pathway

S Lidder, AJ Webb - British journal of clinical pharmacology, 2013 - Wiley Online Library
The discovery that dietary (inorganic) nitrate has important vascular effects came from the
relatively recent realization of the 'nitrate‐nitrite‐nitric oxide (NO) pathway'. Dietary nitrate …

Inorganic nitrate is a possible source for systemic generation of nitric oxide

JO Lundberg, M Govoni - Free Radical Biology and Medicine, 2004 - Elsevier
Nitrate and nitrite have been considered stable inactive end products of nitric oxide (NO).
While several recent studies now imply that nitrite can be reduced to bioactive NO again, the …

Dietary polyphenols: good, bad, or indifferent for your health?

B Halliwell - Cardiovascular research, 2007 - academic.oup.com
Flavonoids and other polyphenolic compounds have powerful antioxidant effects in vitro in
many test systems, but can act as pro-oxidants in some others. Whether pro-oxidant …

Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential

SM Ghosh, V Kapil, I Fuentes-Calvo, KJ Bubb… - …, 2013 - Am Heart Assoc
Elevation of circulating nitrite (NO2−) levels causes vasodilatation and lowers blood
pressure in healthy volunteers. Whether these effects and the underpinning mechanisms …