We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

Life expectancy is increasing and so is the prevalence of age-related non-communicable
diseases (NCDs). Consequently, older people and patients present with multi-morbidities …

Identification of modifiable risk factors provides a crucial approach to the prevention of
dementia. Nutritional or nutrient-dependent risk factors are especially important because …

Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for
vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with …

A systematic review and meta-analysis was undertaken to examine and quantify the effects
of B vitamin supplementation on mood in both healthy and 'at-risk'populations. A systematic …

Increased plasma homocysteine is a risk factor for several pathological disorders. The
present review focused on the role of homocysteine (Hcy) in different population groups …

The biosynthesis of B 12, involving up to 30 different enzyme-mediated steps, only occurs in
bacteria. Thus, most eukaryotes require an external source of B 12, and yet the vitamin …

Elevated levels of oxidative stress could cause and aggravate Alzheimer's disease (AD).
Selenium (Se) is a trace element with antioxidant and anti-inflammatory activity with …

Abstract Context Elevation of homocysteine (Hcy) levels is well-established as a risk factor
for dementia, yet controversy exists regarding whether B-vitamin-mediated reduction of …

Alzheimer's disease (AD) is the most common form of dementia in the elderly population,
affecting over 55 million people worldwide. Histopathological hallmarks of this multifactorial …