IDO1 (indoleamine 2, 3-dioxygenase 1) is a member of a unique class of mammalian haem
dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino …

RNA interference (RNAi) is a natural cellular mechanism that inhibits gene expression in a
sequence-specific manner. In the last decade, RNAi has become a cornerstone in basic …

Serotonin (5‐HT) induces concentration‐dependent metabolic effects in diverse cell types,
including neurons, entherochromaffin cells, adipocytes, pancreatic beta‐cells, fibroblasts …

The interaction between pathogenic microorganisms and their hosts is regulated by
reciprocal survival strategies, including competition for essential nutrients. Though …

Immunotherapy for cancer treatment is achieved through the activation of competent
immune effector cells and the inhibition of immunosuppressive cells, such as myeloid …

Introduction: Lung cancer is a devastating disease with poor overall survival. Despite
significant advances in the treatment of lung cancers using radiochemotherapy, targeted …

Single-stranded (ss) and double-stranded (ds) small interfering RNAs (siRNAs) containing
immunostimulatory RNA motifs can activate innate immunity through Toll-like receptor 7/8 …

Abstract Indoleamine 2, 3-dioxygenase (IDO) is an immunoregulatory enzyme that is
implicated in suppressing T-cell immunity in normal and pathologic settings. Here, we …

Abstract Indoleamine 2, 3-dioxygenase, the l-tryptophan–degrading enzyme, plays a key
role in the powerful immunomodulatory effects on several different types of cells. Because …

Caspase recruitment domain‐containing protein 9 (CARD9) is an adaptor protein and highly
expressed in myeloid cells. Our previous study demonstrates a critical protective effect of …