The development of new methods for the direct functionalization of unactivated C–H bonds
is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic …

Transition metal-catalyzed direct functionalization of C–H bonds is one of the key emerging
strategies that is currently attracting tremendous attention with the aim to provide alternative …

Direct catalytic transformation of C–H bonds to new functionalities has provided a powerful
strategy to synthesize complex molecular scaffolds in a straightforward way. Unstinting …

The area of direct asymmetric functionalization of inert C–H bonds has attracted
considerable attention in recent years. To realize this type of challenging but promising …

Homogeneous transition-metal-catalyzed reactions are indispensable to all facets of modern
chemical synthesis. It is thus difficult to imagine that for much of the early 20th century, the …

Pd (II)-catalyzed enantioselective C–H activation of phenylacetic acids followed by an
intramolecular C–O bond formation afforded chiral benzofuranones. This reaction provides …

A highly enantioselective allylic C–H alkylation reaction of allylarenes with pyrazol-5-ones
has been established by the cooperative catalysis of a chiral palladium complex and chiral …

As a widely existing functional group in organic molecules, the carboxyl group has
numerous advantageous characteristics such as great convenience for further …

A palladium‐catalyzed enantioselective C H arylation of N‐(o‐bromoaryl)‐
diarylphosphinic amides is described for the synthesis of phosphorus compounds bearing a …

A metal-free C–H oxidation for the construction of allylic esters has been developed. The
use of a commercially available and inexpensive catalyst and oxidant, and readily available …