TGF-β signaling from receptors to Smads
A Hata, YG Chen - Cold Spring Harbor perspectives in …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis
Variation in body iron is associated with or causes diseases, including anaemia and iron
overload. Here, we analyse genetic association data on biochemical markers of iron status …
overload. Here, we analyse genetic association data on biochemical markers of iron status …
WANTED–Dead or alive: Myotubularins, a large disease-associated protein family
Myotubularins define a large family of proteins conserved through evolution. Several
members are mutated in different neuromuscular diseases including centronuclear …
members are mutated in different neuromuscular diseases including centronuclear …
Socioeconomic status and DNA methylation from birth through mid-childhood: a prospective study in Project Viva
Aim: We investigated associations of prenatal socioeconomic status (SES) with DNA
methylation at birth, and to explore persistence of associations into early (∼3 years) and …
methylation at birth, and to explore persistence of associations into early (∼3 years) and …
Bone morphogenetic protein signaling: the pathway and its regulation
T Akiyama, LA Raftery, KA Wharton - Genetics, 2024 - academic.oup.com
In the mid-1960s, bone morphogenetic proteins (BMPs) were first identified in the extracts of
bone to have the remarkable ability to induce heterotopic bone. When the Drosophila gene …
bone to have the remarkable ability to induce heterotopic bone. When the Drosophila gene …
BMP growth factor signaling in a biomechanical context
J Kopf, P Paarmann, C Hiepen, D Horbelt, P Knaus - Biofactors, 2014 - Wiley Online Library
Abstract Bone Morphogenetic Proteins (BMPs) are members of the transforming growth
factor‐β superfamily of secreted polypeptide growth factors and are important regulators in a …
factor‐β superfamily of secreted polypeptide growth factors and are important regulators in a …
PTPs emerge as PIPs: protein tyrosine phosphatases with lipid-phosphatase activities in human disease
R Pulido, AW Stoker… - Human molecular …, 2013 - academic.oup.com
Protein tyrosine phosphatases (PTPs) constitute a family of key homeostatic regulators, with
wide implications on physiology and disease. Recent findings have unveiled that the …
wide implications on physiology and disease. Recent findings have unveiled that the …
Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H
Bone morphogenetic proteins (BMPs) belong to the TGF-β superfamily of structurally related
signaling proteins that regulate a wide array of cellular functions. The key step in BMP signal …
signaling proteins that regulate a wide array of cellular functions. The key step in BMP signal …
C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad …
The bone morphogenetic protein (BMP) signaling pathway regulates a wide range of
cellular responses in metazoans. A key step in the canonical BMP signaling is the …
cellular responses in metazoans. A key step in the canonical BMP signaling is the …
Optimal performance objectives in the highly conserved bone morphogenetic protein signaling pathway
R Shaikh, NJ Larson, J Kam, D Hanjaya-Putra… - npj Systems Biology …, 2024 - nature.com
Throughout development, complex networks of cell signaling pathways drive cellular
decision-making across different tissues and contexts. The transforming growth factor β (TGF …
decision-making across different tissues and contexts. The transforming growth factor β (TGF …